Radiolabeling and Bio-distribution study of ICD-85 with Technetium-99m as a cancer treatment agent in mice

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SHIRMARDI SEYED PEZHMAN; ERFANI MOSTAFA; ZARE MIRAKABADI ABBAS; MIRZAEI HAMIDREZA; Mola Masoud

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Journal: Archives of Advances in Biosciences Year:2018 | Volume:9 | Issue:2 Page(s): 1-6

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Title

Radiolabeling and Bio-distribution study of ICD-85 with Technetium-99m as a cancer treatment agent in mice

Author(s)

Keywords

Radiolabeling

Tc-99m

Bio-distribution

Venom

ICD-85

Abstract

ICD-85 is a combination of three poly-peptides, ranging from 10, 000 to 30, 000 Dalton, derived from the Venoms of an Iranian brown snake (Agkistrodon halys) and a yellow scorpion (Hemiscorpius lepturus). Labeling of this ICD-85 was successfully achieved with 99mTc, through direct method using SnF2 as reducing agent. Labeled ICD-85 was injected into mice to determine the excretion pathway. The results show that the maximum labeling yield (>75%) was obtained by using 30 μ g of ICD-85 in phosphate buffer (60 μ l, pH 7. 1) at room temperature. Bio-distribution studies with radiolabeled ICD-85 shows moderate clearance of the complex from blood. The improvement of the immunotherapeutic treatment of cancer requires a better knowledge of the biological actions of the ICD-85 since tissue distribution studies are very important for clinical purpose.

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APA: Copy

SHIRMARDI, SEYED PEZHMAN, ERFANI, MOSTAFA, ZARE MIRAKABADI, ABBAS, MIRZAEI, HAMIDREZA, & Mola, Masoud. (2018). Radiolabeling and Bio-distribution study of ICD-85 with Technetium-99m as a cancer treatment agent in mice. ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES), 9(2), 1-6. SID. https://sid.ir/paper/315926/en

Vancouver: Copy

SHIRMARDI SEYED PEZHMAN, ERFANI MOSTAFA, ZARE MIRAKABADI ABBAS, MIRZAEI HAMIDREZA, Mola Masoud. Radiolabeling and Bio-distribution study of ICD-85 with Technetium-99m as a cancer treatment agent in mice. ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES)[Internet]. 2018;9(2):1-6. Available from: https://sid.ir/paper/315926/en

IEEE: Copy

SEYED PEZHMAN SHIRMARDI, MOSTAFA ERFANI, ABBAS ZARE MIRAKABADI, HAMIDREZA MIRZAEI, and Masoud Mola, “Radiolabeling and Bio-distribution study of ICD-85 with Technetium-99m as a cancer treatment agent in mice,” ARCHIVES OF ADVANCES IN BIOSCIENCES (JOURNAL OF PARAMEDICAL SCIENCES), vol. 9, no. 2, pp. 1–6, 2018, [Online]. Available: https://sid.ir/paper/315926/en

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