WHY 24-H URINE ALBUMIN EXCRETION RATE METHOD STILL IS USED FOR SCREENING OF DIABETIC NEPHROPATHY IN ISFAHAN LABORATORIES?

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TEIMOURY AZAM; IRAJ BIJAN; HEIDARI BENI MOTAHAR; AMINI MASSOUD; HOSSEINI SEYED MOHSEN

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Journal: International Journal of Preventive Medicine Year:2014 | Volume:5 | Issue:3 Page(s): 341-347

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Title

WHY 24-H URINE ALBUMIN EXCRETION RATE METHOD STILL IS USED FOR SCREENING OF DIABETIC NEPHROPATHY IN ISFAHAN LABORATORIES?

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Keywords

ALBUMINURIA

DIABETIC NEPHROPATHY

SCREENING

URINARY ALBUMIN TO CREATININE RATIO

Abstract

Background: The first step in diagnosis of DIABETIC NEPHROPATHY is measurement of albumin in a spot urine sample. The aim of this study was assessment of the accuracy of URINARY ALBUMIN TO CREATININE RATIO (UACR) in random urine specimens (RUS) for microALBUMINURIA and macroALBUMINURIA SCREENING in Iranian diabetic patients.Methods: A total of 200 diabetic patients participated to our study. 24 h timed urine specimens followed by RUS were collected. 24-h urine albumin excretion (24-h urinary albumin excretion (UAE)) and UACR in RUS were measured. Data were analyzed by Pearson’s correlation, receiver operating characteristic (ROC) curve and McNemar test.Results: A total of 165 patients finalized the study. Pearson’s correlation of coefficient for 24-h UAE versus UACR was 0.64. The area under ROC curve for UACR was 0.83 in microALBUMINURIA and 0.91 in macroALBUMINURIA. The cutoff point of 30 mg/g in UACR method had 86% sensitivity and 60% specificity for microALBUMINURIA SCREENING and cut-off point of 300 mg/g had 75% sensitivity and 99% specificity for macroALBUMINURIA SCREENING respectively.Conclusions: UACR in RUS showed acceptable performance as a SCREENING test for diagnosis of both micro and macroALBUMINURIA in Iranian diabetic patients.

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APA: Copy

TEIMOURY, AZAM, IRAJ, BIJAN, HEIDARI BENI, MOTAHAR, AMINI, MASSOUD, & HOSSEINI, SEYED MOHSEN. (2014). WHY 24-H URINE ALBUMIN EXCRETION RATE METHOD STILL IS USED FOR SCREENING OF DIABETIC NEPHROPATHY IN ISFAHAN LABORATORIES?. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 5(3), 341-347. SID. https://sid.ir/paper/316058/en

Vancouver: Copy

TEIMOURY AZAM, IRAJ BIJAN, HEIDARI BENI MOTAHAR, AMINI MASSOUD, HOSSEINI SEYED MOHSEN. WHY 24-H URINE ALBUMIN EXCRETION RATE METHOD STILL IS USED FOR SCREENING OF DIABETIC NEPHROPATHY IN ISFAHAN LABORATORIES?. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2014;5(3):341-347. Available from: https://sid.ir/paper/316058/en

IEEE: Copy

AZAM TEIMOURY, BIJAN IRAJ, MOTAHAR HEIDARI BENI, MASSOUD AMINI, and SEYED MOHSEN HOSSEINI, “WHY 24-H URINE ALBUMIN EXCRETION RATE METHOD STILL IS USED FOR SCREENING OF DIABETIC NEPHROPATHY IN ISFAHAN LABORATORIES?,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 5, no. 3, pp. 341–347, 2014, [Online]. Available: https://sid.ir/paper/316058/en

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