ROLES OF THE NUCLEUS ACCUMBENS (SHELL) IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED BEHAVIOR IN FREELY MOVING RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KARIMI SARA; RADAHMADI MARYAM; FAZILATI MOHAMMAD; AZIZI MALEKABADI HAMID; ALAEI HOJJATALLAH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Preventive Medicine Year:2014 | Volume:5 | Issue:3 Page(s): 262-268

Download Full-Text

View:

238

Download:

131

Cites:

Information Journal Paper

Title

ROLES OF THE NUCLEUS ACCUMBENS (SHELL) IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED BEHAVIOR IN FREELY MOVING RATS

Author(s)

Keywords

CONDITIONED-PLACE PREFERENCE

MORPHINE

NUCLEUS ACCUMBENS

RAT

Abstract

Background: The NUCLEUS ACCUMBENS (NAc) is a part of the rewarding cortico-mesolimbic dopamine (DA) pathway. This is a heterogeneous structure divided in two sub regions termed core and shell. DA function in the NAc is critical for goal-oriented behaviors, including those motivated by drug and brain stimulation reward. In the CONDITIONED-PLACE PREFERENCE (CPP) paradigm, a test assessing animal’s ability to associate drug-induced effects with environmental cause to quantify drug reward for example MORPHINE.Methods: In the present study, we investigated the influence of electrical stimulation with different current intensities on (25 and 100 mA) with and without an effective dose of MORPHINE (0.5 and 5 mg/kg) on CPP. Results: Subcutaneous administration of MORPHINE 5 mg/kg produced significant CPP in comparison with saline group. Our findings also showed that electrical stimulation of NAc (100 mA) significantly (P<0.01) suppressed MORPHINE-induced CPP that reveals impaired learning and memory formation in the process of conditioning. We found that MORPHINE-induced CPP can be successfully suppressed by current intensity (100 mA). It was probably due to decreasing of dopamine contents and its metabolites in the NAc. Current intensity (100 mA) in combination with ineffective dose of MORPHINE (0.5 mg/kg) increased MORPHINE-induced CPP probability via the prove reward system.Conclusions: Since stimulation of dopaminergic neurons increases tendency to dependence to MORPHINE, therefore in the present study, the stimulation of the NAc suppressed MORPHINE-induced CPP that this shows impairment of learning and memory formation.

Cites

No record.

References

No record.

Cite

APA: Copy

KARIMI, SARA, RADAHMADI, MARYAM, FAZILATI, MOHAMMAD, AZIZI MALEKABADI, HAMID, & ALAEI, HOJJATALLAH. (2014). ROLES OF THE NUCLEUS ACCUMBENS (SHELL) IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED BEHAVIOR IN FREELY MOVING RATS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 5(3), 262-268. SID. https://sid.ir/paper/316062/en

Vancouver: Copy

KARIMI SARA, RADAHMADI MARYAM, FAZILATI MOHAMMAD, AZIZI MALEKABADI HAMID, ALAEI HOJJATALLAH. ROLES OF THE NUCLEUS ACCUMBENS (SHELL) IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED BEHAVIOR IN FREELY MOVING RATS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2014;5(3):262-268. Available from: https://sid.ir/paper/316062/en

IEEE: Copy

SARA KARIMI, MARYAM RADAHMADI, MOHAMMAD FAZILATI, HAMID AZIZI MALEKABADI, and HOJJATALLAH ALAEI, “ROLES OF THE NUCLEUS ACCUMBENS (SHELL) IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED CONDITIONED BEHAVIOR IN FREELY MOVING RATS,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 5, no. 3, pp. 262–268, 2014, [Online]. Available: https://sid.ir/paper/316062/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops