Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

221
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

142
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

PROTECTIVE ROLE OF CROCIN AGAINST NICOTINE‑INDUCED DAMAGES ON MALE MICE LIVER

Pages

  0-0

Keywords

Abstract

 Background: NICOTINE is a major pharmacologically active substance in cigarette smoke. It is mainly metabolized in LIVER and causes devastating effects. CROCIN is the chemical ingredient primarily responsible for the color of saffron. It has different pharmacological effects such as antioxidant and anticancer. This study was designed to evaluate the protective role of CROCIN against NICOTINE on the LIVER of MICE. Methods: Forty‑eight MICE were equally divided into 8 groups; control (normal saline), NICOTINE (2.5 mg/kg), CROCIN (12.5, 25 and 50 mg/kg) and CROCIN plus NICOTINE treated groups. Saline, CROCIN, NICOTINE and CROCIN/nicotine (once a day) were intraperitoneally injected for 4 weeks. The LIVER weight and histology, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and serum nitric oxide levels have been studied. Results: The results indicated that NICOTINE administration significantly decreased LIVER weight (48.37%) and increased the mean diameter of hepatocyte (239%), central hepatic vein (28.45%), LIVER enzymes level (ALP 29.43%, AST 21.81%, ALT 21.55%), and blood serum nitric oxide level (57.18%) compared to saline group (P < 0.05). However, CROCIN and CROCIN plus NICOTINE administration significantly boosted LIVER weight (49.54%) and decreased the mean diameter of hepatocyte (40.48%), central hepatic vein (15.44%), LIVER enzymes (ALP 22.02%, AST 19.05%, ALT 23.11%), and nitric oxide levels (35.80%) in all groups compared to NICOTINE group (percentages represent the maximum dose) (P < 0.05). Conclusions: CROCIN showed its partly protective effect against NICOTINE‑induced LIVER toxicity.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    JALILI, CYRUS, TABATABAEI, HADIS, KAKABERIEI, SEYRAN, ROSHANKHAH, SHIVA, & SALAHSHOOR, MOHAMMAD REZA. (2015). PROTECTIVE ROLE OF CROCIN AGAINST NICOTINE?INDUCED DAMAGES ON MALE MICE LIVER. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 6(9), 0-0. SID. https://sid.ir/paper/316266/en

    Vancouver: Copy

    JALILI CYRUS, TABATABAEI HADIS, KAKABERIEI SEYRAN, ROSHANKHAH SHIVA, SALAHSHOOR MOHAMMAD REZA. PROTECTIVE ROLE OF CROCIN AGAINST NICOTINE?INDUCED DAMAGES ON MALE MICE LIVER. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2015;6(9):0-0. Available from: https://sid.ir/paper/316266/en

    IEEE: Copy

    CYRUS JALILI, HADIS TABATABAEI, SEYRAN KAKABERIEI, SHIVA ROSHANKHAH, and MOHAMMAD REZA SALAHSHOOR, “PROTECTIVE ROLE OF CROCIN AGAINST NICOTINE?INDUCED DAMAGES ON MALE MICE LIVER,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 6, no. 9, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/316266/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top