CYTOMEGALOVIRUS, TOXOPLASMA GONDII AND RUBELLA VERTICAL TRANSMISSION RATES ACCORDING TO MID‑TRIMESTER AMNIOCENTESIS: A RETROSPECTIVE STUDY

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MARGIOULA SIARKOU CHRYSOULA; KALOGIANNIDIS IOANNIS; PETOUSIS STAMATIOS; PRAPA STELLA; DAGKLIS THEMISTOKLIS; MAMOPOULOS APOSTOLOS; PRAPAS NIKOS; ROUSSO DAVID

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Journal: International Journal of Preventive Medicine Year:2015 | Volume:6 | Issue:4 Page(s): 0-0

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Title

CYTOMEGALOVIRUS, TOXOPLASMA GONDII AND RUBELLA VERTICAL TRANSMISSION RATES ACCORDING TO MID‑TRIMESTER AMNIOCENTESIS: A RETROSPECTIVE STUDY

Author(s)

Keywords

AMNIOCENTESIS

CYTOMEGALOVIRUS

INFECTION

RUBELLA

TOXOPLASMA

VERTICAL TRANSMISSION

Abstract

Objective: To examine VERTICAL TRANSMISSION rates of CYTOMEGALOVIRUS, TOXOPLASMA Gondii and RUBELLA INFECTIONs according to amniotic fluid PCR analysis.Methods: A retrospective analysis of mid-trimester amniocenteses performed in in pregnancies with diagnosed maternal INFECTION by Cytomegavirus (CMV), RUBELLA or TOXOPLASMA gondii during 1994-2008 was performed. VERTICAL TRANSMISSION rates were observed according to the presence of the infectious agent’s DNA in the amniotic fluid. A univariate regression model was also performed to investigate possible correlations between transmission and epidemiological parameters.Results: Overall, 7033 amniocenteses were performed during study’s period, of which 166 (2.4%) with the indication of maternal INFECTION by CMV, RUBELLA or TOXOPLASMA. Mean maternal age was 27.4 ± 2.5 years and the mean gestational age at AMNIOCENTESIS was 18.7±2.5 weeks. VERTICAL TRANSMISSION was observed in 21 cases (12.7%). Transmission rate was 17.3% in cases with INFECTION from CMV, 9.5% from TOXOPLASMA gondii and 7.8% from RUBELLA (P=.05). Maternal age was the only parameter being significantly associated with increased risk for VERTICAL TRANSMISSION (P=.04).Conclusions: According to our results, overall VERTICAL TRANSMISSION rate marginally exceeds 10%. CMV INFECTION is characterized by relatively higher transplacental transmission rate, while increased maternal age appears to be associated with a higher risk for VERTICAL TRANSMISSION.

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APA: Copy

MARGIOULA SIARKOU, CHRYSOULA, KALOGIANNIDIS, IOANNIS, PETOUSIS, STAMATIOS, PRAPA, STELLA, DAGKLIS, THEMISTOKLIS, MAMOPOULOS, APOSTOLOS, PRAPAS, NIKOS, & ROUSSO, DAVID. (2015). CYTOMEGALOVIRUS, TOXOPLASMA GONDII AND RUBELLA VERTICAL TRANSMISSION RATES ACCORDING TO MID?TRIMESTER AMNIOCENTESIS: A RETROSPECTIVE STUDY. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 6(4), 0-0. SID. https://sid.ir/paper/316312/en

Vancouver: Copy

MARGIOULA SIARKOU CHRYSOULA, KALOGIANNIDIS IOANNIS, PETOUSIS STAMATIOS, PRAPA STELLA, DAGKLIS THEMISTOKLIS, MAMOPOULOS APOSTOLOS, PRAPAS NIKOS, ROUSSO DAVID. CYTOMEGALOVIRUS, TOXOPLASMA GONDII AND RUBELLA VERTICAL TRANSMISSION RATES ACCORDING TO MID?TRIMESTER AMNIOCENTESIS: A RETROSPECTIVE STUDY. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2015;6(4):0-0. Available from: https://sid.ir/paper/316312/en

IEEE: Copy

CHRYSOULA MARGIOULA SIARKOU, IOANNIS KALOGIANNIDIS, STAMATIOS PETOUSIS, STELLA PRAPA, THEMISTOKLIS DAGKLIS, APOSTOLOS MAMOPOULOS, NIKOS PRAPAS, and DAVID ROUSSO, “CYTOMEGALOVIRUS, TOXOPLASMA GONDII AND RUBELLA VERTICAL TRANSMISSION RATES ACCORDING TO MID?TRIMESTER AMNIOCENTESIS: A RETROSPECTIVE STUDY,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 6, no. 4, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/316312/en

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