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Information Journal Paper

Title

BRIEF COMMUNICATION: PREVENTIVE ROLE OF ENDOTHELIN ANTAGONIST ON KIDNEY ISCHEMIA: REPERFUSION INJURY IN MALE AND FEMALE RATS

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Abstract

 Background: Renal ischemia/reperfusion injury (RIRI) is the most common cause of acute KIDNEYinjury. We tested the protective role of ENDOTHELIN‑1 receptor blocker; BOSENTAN (BOS) in animalmodel of RIRI in two different GENDERs.Methods: Male and female Wistar rats were assigned as sham operated (sham), control group(ischemia), and case group (ischemia+BOS) treated with BOS (50 mg/kg) 2 h before bilateralkidney ischemia induced by clamping renal vessels for 45 min followed by 24 h of renal reperfusion.Results: The RIRI significantly increased the serum levels of blood urea nitrogen and creatininein both GENDERs (P<0.05). These values were significantly decreased by BOS in both GENDERs.In male rats, the serum levels of malondialdehyde in the ischemia+BOS group were decreasedsignificantly when compared with ischemia group (P<0.05).Conclusions: BOS can be used in both GENDERs to attenuate KIDNEY ischemia injury possiblydue to its effect in the renal vascular system.

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    APA: Copy

    ESMALIAN AFYOUNI, NAZGOL, HALILI, HANIEH, MOSLEMI, FATEMEH, NEMATBAKHSH, MAHDI, TALEBI, ARDESHIR, Shirdavani, Soheila, & MALEKI, MARYAM. (2015). BRIEF COMMUNICATION: PREVENTIVE ROLE OF ENDOTHELIN ANTAGONIST ON KIDNEY ISCHEMIA: REPERFUSION INJURY IN MALE AND FEMALE RATS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, 6(-), 0-0. SID. https://sid.ir/paper/316409/en

    Vancouver: Copy

    ESMALIAN AFYOUNI NAZGOL, HALILI HANIEH, MOSLEMI FATEMEH, NEMATBAKHSH MAHDI, TALEBI ARDESHIR, Shirdavani Soheila, MALEKI MARYAM. BRIEF COMMUNICATION: PREVENTIVE ROLE OF ENDOTHELIN ANTAGONIST ON KIDNEY ISCHEMIA: REPERFUSION INJURY IN MALE AND FEMALE RATS. INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE[Internet]. 2015;6(-):0-0. Available from: https://sid.ir/paper/316409/en

    IEEE: Copy

    NAZGOL ESMALIAN AFYOUNI, HANIEH HALILI, FATEMEH MOSLEMI, MAHDI NEMATBAKHSH, ARDESHIR TALEBI, Soheila Shirdavani, and MARYAM MALEKI, “BRIEF COMMUNICATION: PREVENTIVE ROLE OF ENDOTHELIN ANTAGONIST ON KIDNEY ISCHEMIA: REPERFUSION INJURY IN MALE AND FEMALE RATS,” INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE, vol. 6, no. -, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/316409/en

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