MORPHOLOGICAL AND BACTERICIDAL EFFECTS OF DIFFERENT ANTIBIOTICS ON HELICOBACTER PYLORI

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FAGHRI JAMSHID; POURSINA FARKHONDEH; MOGHIM SHARAREH; ZARKESH ESFAHANI HAMID; NASR ESFAHANI BAHRAM; FAZELI HOSSEIN; MIRZAEI NASRIN; JAMSHIDIAN AZAM; GHASEMIAN SAFAEI HAJIEH

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Journal: Jundishapur Journal of Microbiology Year:2014 | Volume:7 | Issue:1 Page(s): 0-0

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Title

MORPHOLOGICAL AND BACTERICIDAL EFFECTS OF DIFFERENT ANTIBIOTICS ON HELICOBACTER PYLORI

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Keywords

HELICOBACTER PYLORI

COCCOID BACTERIA

ANTIBIOTICS

SUSCEPTIBILITY

Abstract

Background: HELICOBACTER PYLORI (H. pylori) is a spiral Gram negative bacteria that can transform to the coccoid form in adverse conditions.Objectives: The aim of this study was to determine the in vitro morphological and bactericidal effects of metronidazole, amoxicillin and clarithromycin on H. pylori.Materials and Methods: The standard strain 26695 of H. pylori was cultured on Brucella agar (BA) and the minimum inhibitory concentrations (MICs) of three ANTIBIOTICS were determined by E-test method. The bacteria were exposed to ANTIBIOTICS at 1/2 MIC, MIC and 2X MIC concentrations in Brucella broth (BB). Induced coccoid forms were confirmed by Gram staining and light microscopy. The viability of cells as well as the SUSCEPTIBILITY of viable coccoids to ANTIBIOTICS were examined using the flow cytometry method.Results: All of the three ANTIBIOTICS at sub-MIC induced coccoid forms. The highest rates of coccoids (>90%) were induced at 0.008 mg/ mL concentration (1/2 MIC) of amoxicillin, 72 hours postexposure. Metronidazole and clarithromycin with 1/2 MIC (0.5 and 0.125 mg/mL respectively) induced lower rates of coccoid forms (60% and 40% respectively). Potent bactericidal effects on coccoids were observed with Metronidazole at 2X MIC and clarithromycin at MIC (0.25 mg/mL) (80-90%). Amoxicillin with MIC and 2X MIC had no bactericidal effect on coccoid forms.Conclusions: Despite the good in vitro bactericidal effect of amoxicillin on spiral forms of H. pylori, this antibiotic has little effect on induced coccoids that may develop after the inappropriatein vivo antibacterial treatment. Hence, for successful therapy, it is essential not only to eradicate the spiral forms, but to eliminate the viable coccoids.

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MORPHOLOGICAL AND BACTERICIDAL EFFECTS OF AMIKACIN, MEROPENEM AND IMIPENEM ON PSEUDOMONAS AERUGINOSA

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APA: Copy

FAGHRI, JAMSHID, POURSINA, FARKHONDEH, MOGHIM, SHARAREH, ZARKESH ESFAHANI, HAMID, NASR ESFAHANI, BAHRAM, FAZELI, HOSSEIN, MIRZAEI, NASRIN, JAMSHIDIAN, AZAM, & GHASEMIAN SAFAEI, HAJIEH. (2014). MORPHOLOGICAL AND BACTERICIDAL EFFECTS OF DIFFERENT ANTIBIOTICS ON HELICOBACTER PYLORI . JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 7(1), 0-0. SID. https://sid.ir/paper/317338/en

Vancouver: Copy

FAGHRI JAMSHID, POURSINA FARKHONDEH, MOGHIM SHARAREH, ZARKESH ESFAHANI HAMID, NASR ESFAHANI BAHRAM, FAZELI HOSSEIN, MIRZAEI NASRIN, JAMSHIDIAN AZAM, GHASEMIAN SAFAEI HAJIEH. MORPHOLOGICAL AND BACTERICIDAL EFFECTS OF DIFFERENT ANTIBIOTICS ON HELICOBACTER PYLORI . JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2014;7(1):0-0. Available from: https://sid.ir/paper/317338/en

IEEE: Copy

JAMSHID FAGHRI, FARKHONDEH POURSINA, SHARAREH MOGHIM, HAMID ZARKESH ESFAHANI, BAHRAM NASR ESFAHANI, HOSSEIN FAZELI, NASRIN MIRZAEI, AZAM JAMSHIDIAN, and HAJIEH GHASEMIAN SAFAEI, “MORPHOLOGICAL AND BACTERICIDAL EFFECTS OF DIFFERENT ANTIBIOTICS ON HELICOBACTER PYLORI ,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 7, no. 1, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/317338/en

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