EFFECT OF EFFLUX PUMP INHIBITOR CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE ON THE MINIMUM INHIBITORY CONCENTRATION OF CIPROFLOXACIN IN ACINETOBACTER BAUMANNII CLINICAL ISOLATES

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ARDEBILI ABDOLLAH; TALEBI MALIHEH; AZIMI LEILA; RASTEGAR LARI ABDOLAZIZ

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Journal Paper

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Journal: Jundishapur Journal of Microbiology Year:2014 | Volume:7 | Issue:1 Page(s): 0-0

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Title

EFFECT OF EFFLUX PUMP INHIBITOR CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE ON THE MINIMUM INHIBITORY CONCENTRATION OF CIPROFLOXACIN IN ACINETOBACTER BAUMANNII CLINICAL ISOLATES

Author(s)

ARDEBILI ABDOLLAH | TALEBI MALIHEH | AZIMI LEILA | RASTEGAR LARI ABDOLAZIZ | Issue Writer Certificate

Keywords

ACINETOBACTER BAUMANNII

BURN

CIPROFLOXACIN

EFFLUX PUMPS

CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE

Abstract

Background: ACINETOBACTER BAUMANNII is an important human pathogen with increasing notoriety in the recent years, as a causative organism of drug resistant nosocomial infections, particularly in immunocompromised patients hospitalized in BURN centers.Objectives: The aim of this study was to determinate the role of efflux pump (s) in CIPROFLOXACIN resistance of A. baumannii strains isolated from BURN patients.Materials and Methods: Sixty-five A. baumannii strains were isolated from the BURN patients hospitalized in Motahari BURNs and Reconstruction Center in Tehran, Iran. Susceptibility test to CIPROFLOXACIN was carried out by disk agar diffusion and agar dilution methods, according to the CLSI guidelines. Activity of the efflux system was evaluated using efflux pump inhibitor CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE (CCCP).Results: All Acinetobacter isolates were resistant to CIPROFLOXACIN. The Minimum inhibitory concentration (MIC) range of CIPROFLOXACIN in isolates was 4 to 128 mg/mL or greater. Moreover, susceptibility of strains to CIPROFLOXACIN was highly increased in the presence of efflux pump inhibitor; So that, for 86.1% (56/65) of isolates, CCCP reduced the MIC by 2 to 64 folds.Conclusions: Our findings are suggestive that efflux-based system may play a role in fluoroquinolone resistance in A. baumannii isolates, affecting hospitalized patients. The ability of Acinetobacter to acquire resistance to these potent antimicrobials by the efflux pump mechanism is a concern. Therefore, new strategies are required in order to eliminate the efflux transport activity from the resistant bacteria causing nosocomial infections and provide more appropriate approaches for treatment and management of troubling infections.

Cites

EFFLUX PUMP INHIBITOR PHENYLALANINE-ARGININE Β-NAPHTHYLAMIDE EFFECT ON THE MINIMUM INHIBITORY CONCENTRATION OF IMIPENEM IN ACINETOBACTER BAUMANNII STRAINS ISOLATED FROM HOSPITALIZED PATIENTS IN SHAHID MOTAHARI BURN HOSPITAL, TEHRAN, IRAN

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APA: Copy

ARDEBILI, ABDOLLAH, TALEBI, MALIHEH, AZIMI, LEILA, & RASTEGAR LARI, ABDOLAZIZ. (2014). EFFECT OF EFFLUX PUMP INHIBITOR CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE ON THE MINIMUM INHIBITORY CONCENTRATION OF CIPROFLOXACIN IN ACINETOBACTER BAUMANNII CLINICAL ISOLATES . JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 7(1), 0-0. SID. https://sid.ir/paper/317346/en

Vancouver: Copy

ARDEBILI ABDOLLAH, TALEBI MALIHEH, AZIMI LEILA, RASTEGAR LARI ABDOLAZIZ. EFFECT OF EFFLUX PUMP INHIBITOR CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE ON THE MINIMUM INHIBITORY CONCENTRATION OF CIPROFLOXACIN IN ACINETOBACTER BAUMANNII CLINICAL ISOLATES . JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2014;7(1):0-0. Available from: https://sid.ir/paper/317346/en

IEEE: Copy

ABDOLLAH ARDEBILI, MALIHEH TALEBI, LEILA AZIMI, and ABDOLAZIZ RASTEGAR LARI, “EFFECT OF EFFLUX PUMP INHIBITOR CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE ON THE MINIMUM INHIBITORY CONCENTRATION OF CIPROFLOXACIN IN ACINETOBACTER BAUMANNII CLINICAL ISOLATES ,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 7, no. 1, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/317346/en

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