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Information Journal Paper

Title

LEVELS OF TRANSFORMING GROWTH FACTOR-BETA AFTER IMMUNIZATION OF MICE WITH IN VIVO PREPARED TOXOPLASMA GONDII EXCRETORY/SECRETORY PROTEINS

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Abstract

 Background: Zoonotic parasite TOXOPLASMA gondii has a high prevalence in human populations. A suitable vaccine for animals can stop the transmission of infection between animal and human.Objectives: The aim of this study was to evaluate in vivo prepared excretory/secretory antigens (E/SA) as a potential candidate for IMMUNIZATION against the parasite and its effect on the production of TRANSFORMING GROWTH FACTOR-BETA (TGF-b).Materials and Methods: TOXOPLASMA gondii tachyzoites were inoculated in the peritoneal cavity of mice and E/SA was harvested and used in animal IMMUNIZATION with and without adjuvant. Serum levels of anti-E/SA antibodies and TGF-b were measured in days 0, 3, 7, 14, 28 and 56 after IMMUNIZATION using ELISA technique. The measurements were statistically analyzed.Results: Our results showed that the serum levels of anti-E/SA immunoglobulins significantly increased in all of the immunized groups. The differences of the serum levels of TGF-b between the groups were statistically significant at days 28 and 56 after IMMUNIZATION with E/SA.Conclusions: Based on our study, in vivo prepared E/SA may be considered as a good candidate for animal IMMUNIZATION.

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    APA: Copy

    ABDOLLAHI, SEYED HOSSEIN, AYOOBI, FATEMEH, KHORRAMDELAZAD, HOSSEIN, NASIRI AHMADABADI, BEHZAD, REZAYATI, MOHAMMADTAGHI, KAZEMI ARABABADI, MOHAMMAD, & ZARE BIDAKI, MOHAMMAD. (2015). LEVELS OF TRANSFORMING GROWTH FACTOR-BETA AFTER IMMUNIZATION OF MICE WITH IN VIVO PREPARED TOXOPLASMA GONDII EXCRETORY/SECRETORY PROTEINS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 8(5), 0-0. SID. https://sid.ir/paper/317545/en

    Vancouver: Copy

    ABDOLLAHI SEYED HOSSEIN, AYOOBI FATEMEH, KHORRAMDELAZAD HOSSEIN, NASIRI AHMADABADI BEHZAD, REZAYATI MOHAMMADTAGHI, KAZEMI ARABABADI MOHAMMAD, ZARE BIDAKI MOHAMMAD. LEVELS OF TRANSFORMING GROWTH FACTOR-BETA AFTER IMMUNIZATION OF MICE WITH IN VIVO PREPARED TOXOPLASMA GONDII EXCRETORY/SECRETORY PROTEINS. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2015;8(5):0-0. Available from: https://sid.ir/paper/317545/en

    IEEE: Copy

    SEYED HOSSEIN ABDOLLAHI, FATEMEH AYOOBI, HOSSEIN KHORRAMDELAZAD, BEHZAD NASIRI AHMADABADI, MOHAMMADTAGHI REZAYATI, MOHAMMAD KAZEMI ARABABADI, and MOHAMMAD ZARE BIDAKI, “LEVELS OF TRANSFORMING GROWTH FACTOR-BETA AFTER IMMUNIZATION OF MICE WITH IN VIVO PREPARED TOXOPLASMA GONDII EXCRETORY/SECRETORY PROTEINS,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 8, no. 5, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/317545/en

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