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Title

Higher Serum Levels of Type I Interferon Receptor in Adults with Chronic Hepatitis B Leading to Hepatitis B Surface Antigen Clearance

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Abstract

 Background: Loss of hepatitis B surface antigen (HBsAg) in Chronic Hepatitis B (CHB) infection is a favorable outcome. Type I interferon (IFNI) has an essential role to fight virus infections when they bind to the IFN- / receptor (IFNAR). Free-circulating IFNARs, known as IFNAR2, perform as carrier proteins to keep the ligands from proteolysis as well as antagonists for ligand binding. Objectives: In this study, we evaluated the HBsAg titer and IFNAR2 in serum baseline of a subcohort of Iranian HBeAg-negative patients with Chronic Hepatitis B. Methods: Sixty-four patients who spontaneously cleared HBsAg and 100 Chronic Hepatitis B patients enrolled in this study for assessment of the serum levels of HBsAg and IFNAR2. Results: Serum levels of HBsAg and IFNAR2 were both powerfully associated with loss of HBsAg. The baseline HBsAg titer was significantly lower (333. 72 1300 IU/mL vs 3811 6779 IU/mL, P = 0. 00) and the IFNAR2 serum level was significantly higher (1. 64 0. 6 vs 0. 87 0. 5 ng/mL, P = 0. 00) in those who cleared HBsAg compared to the CHB patients. Conclusions: These findings indicated the association of the HBsAg titer and serum IFNAR2 in HBsAg clearance in hepatitis B virusinfected patients. In consequence, immune mechanisms related to IFN- / signaling might be responsible in CHB outcome.

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    APA: Copy

    MOHAMADKHANI, ASHRAF, BESHARAT, SIMA, Gol Jah Rad, Golnosh, Pour Dadash Asiabar, Akbar, ROSHANDEL, GHOLAMREZA, POURSHAMS, AKRAM, & POUSTCHI, HOSSEIN. (2017). Higher Serum Levels of Type I Interferon Receptor in Adults with Chronic Hepatitis B Leading to Hepatitis B Surface Antigen Clearance. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 10(3), 0-0. SID. https://sid.ir/paper/317692/en

    Vancouver: Copy

    MOHAMADKHANI ASHRAF, BESHARAT SIMA, Gol Jah Rad Golnosh, Pour Dadash Asiabar Akbar, ROSHANDEL GHOLAMREZA, POURSHAMS AKRAM, POUSTCHI HOSSEIN. Higher Serum Levels of Type I Interferon Receptor in Adults with Chronic Hepatitis B Leading to Hepatitis B Surface Antigen Clearance. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2017;10(3):0-0. Available from: https://sid.ir/paper/317692/en

    IEEE: Copy

    ASHRAF MOHAMADKHANI, SIMA BESHARAT, Golnosh Gol Jah Rad, Akbar Pour Dadash Asiabar, GHOLAMREZA ROSHANDEL, AKRAM POURSHAMS, and HOSSEIN POUSTCHI, “Higher Serum Levels of Type I Interferon Receptor in Adults with Chronic Hepatitis B Leading to Hepatitis B Surface Antigen Clearance,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 10, no. 3, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/317692/en

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