Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

250
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

235
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

In vitro Evaluation of the Effects of Fluconazole and Nano-Fluconazole on Aspergillus flavus and A. fumigatus Isolates

Pages

  0-0

Abstract

 Background: Increasing azole resistance among Aspergillus strains was observed over the last decade. For this reason, viable alternatives for the current medicines are required. Objectives: The current study aimed at producing Fluconazole-loaded liposomal nanoparticles and comparing in vitro antifungal activity of Fluconazole and nano-Fluconazole on Aspergillus flavus and A. fumigatus species isolated from patients and poultry. Methods: Fifty isolates of A. flavus and A. fumigatus were collected from visceral and superficial fungal lesions of humans as well as pulmonary fungal infection of poultry. Liposomal nanoparticles were prepared by thin-film hydration method, using soybean lecithin, cholesterol, and Fluconazole in a ratio of 10: 1: 1. The nanoparticles were analyzed in terms of size, zeta potential, and morphology. Antifungal susceptibility testing was carried out to examine and evaluate the minimum inhibitory concentration (MIC) of Fluconazole and nano-Fluconazole against Aspergillus species by the standard method of broth microdilution as described in CLSI (the clinical and laboratory standards institute)-M38A2. Results: The particle size of liposomes containing Fluconazole was 88. 9 12. 1 nm and its zeta potential was-20. 12 1. 88mv. Nanoliposomes containing Fluconazole significantly reduced the MIC against A. flavus (P = 0. 0005) and A. fumigatus (P < 0. 0001). Conclusions: The results of the current in vitro study showed that nano-Fluconazole has better antifungal effects than the common form of drug on A. flavus and A. fumigatus species. The current study showed the antifungal activity of nano-drugs.

Cites

References

  • No record.

    • Cite

    APA: Copy

    Sarrafha, Mohammad Reza, HASHEMI, SEYED JAMAL, REZAEI, SASAN, & BAYAT, MANSOUR. (2018). In vitro Evaluation of the Effects of Fluconazole and Nano-Fluconazole on Aspergillus flavus and A. fumigatus Isolates. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 11(6), 0-0. SID. https://sid.ir/paper/317740/en

    Vancouver: Copy

    Sarrafha Mohammad Reza, HASHEMI SEYED JAMAL, REZAEI SASAN, BAYAT MANSOUR. In vitro Evaluation of the Effects of Fluconazole and Nano-Fluconazole on Aspergillus flavus and A. fumigatus Isolates. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2018;11(6):0-0. Available from: https://sid.ir/paper/317740/en

    IEEE: Copy

    Mohammad Reza Sarrafha, SEYED JAMAL HASHEMI, SASAN REZAEI, and MANSOUR BAYAT, “In vitro Evaluation of the Effects of Fluconazole and Nano-Fluconazole on Aspergillus flavus and A. fumigatus Isolates,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 11, no. 6, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/317740/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top