مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Detection of Helicobacter pylori in the Bronchoalveolar Lavage of Patients with Lung Cancer Using Real-Time PCR

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Abstract

 Background: Lungcancer isoneof themostcommoncauses of death worldwide. Althoughsmokingandenvironmental pollutants are the most important risk factors of lung cancer, the role of infectious causes should also be considered in the pathogenesis and progress of lung cancer. Objectives: This study examined the relationship between Helicobacter pylori and lung cancer through serology, Real-Time PCR, and urease tests. Methods: This descriptive cross-sectional study was conducted on 52 adult patients with lung cancerwhowere selected after having their history taken and being physically examined by a pulmonologist. Then, the patients underwent a bronchoscopy, a BAL, and biopsy sampling. A urease test was run for each biopsy sample, Real-Time PCR was used for each BAL sample, and H. pylori serology was used for each patient’ s serum. Results: The patients’ average age was 60. 65 9. 15 years; 11. 5% were female and 88. 5% were male. The prevalence of H. pylori in lung cancer patients was 11. 5% according to the BAL PCR test, 92. 3% according to the serology test, and 3. 8% according to the urease test. Conclusions: The results demonstrated an association between of lung cancer and H. Pylori infection via the hypothesis of direct damage and chronic inflammation through inhalation and aspiration and the systematic immune response induced by H. pylori colonization. Helicobacter pylori, together with a host’ s genetic predisposition and other environmental risk factors, could be attributed to the induction of lung cancer.

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    APA: Copy

    SAMAREH FEKRI, MITRA, HASHEMI BAJGANI, SAYED MEHDI, Shafahi, Ahmad, Asadi Zarandi, Mahbobeh, Mollaie, Hamid, & Jamali Paghalhe, Arshia. (2016). Detection of Helicobacter pylori in the Bronchoalveolar Lavage of Patients with Lung Cancer Using Real-Time PCR. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(11), 0-0. SID. https://sid.ir/paper/317752/en

    Vancouver: Copy

    SAMAREH FEKRI MITRA, HASHEMI BAJGANI SAYED MEHDI, Shafahi Ahmad, Asadi Zarandi Mahbobeh, Mollaie Hamid, Jamali Paghalhe Arshia. Detection of Helicobacter pylori in the Bronchoalveolar Lavage of Patients with Lung Cancer Using Real-Time PCR. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2016;9(11):0-0. Available from: https://sid.ir/paper/317752/en

    IEEE: Copy

    MITRA SAMAREH FEKRI, SAYED MEHDI HASHEMI BAJGANI, Ahmad Shafahi, Mahbobeh Asadi Zarandi, Hamid Mollaie, and Arshia Jamali Paghalhe, “Detection of Helicobacter pylori in the Bronchoalveolar Lavage of Patients with Lung Cancer Using Real-Time PCR,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 9, no. 11, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/317752/en

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