مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

190
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

127
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

The Frequency, Antifungal Susceptibility and Enzymatic Profiles of Candida Species Isolated from Neutropenic Patients

Pages

  0-0

Abstract

 Background: Neutropenia, as a predisposing factor for invasive candidiasis, is defined as a reduction in neutrophil count to less than 1500/mm3. It is a common condition in patients with hematological malignancy and cytostatic chemotherapy. Extensive chemotherapy and prophylaxis with antifungals have increased the resistance of Candida isolates to antifungal drugs. Although, Candida albicans is the most common causative agent among Neutropenic Patients, there is an increasing rate of non-albicans species. Extracellular Enzymes activity pattern and antifungal agent sensitivity profiles are two important factors for spreading resistant strains. Objectives: The aim of the present study was to identify the Candida strains isolated from hospitalized Neutropenic Patients. The patterns of Antifungal Susceptibility of the causative agents to antifungals and the Extracellular Enzymes activity of the isolates were also evaluated. Patients and Methods: In the present study, 243 urine and 243 oral swab samples were collected from Neutropenic Patients and inoculated on CHROMagar Candida. In addition, 100 blood samples were also inoculated in biphasic Brain Heart Infusion medium. Several yeast isolates were isolated from samples and identified by classical and molecular techniques. The profiles of Extracellular Enzymes and the susceptibility of recovered agents to amphotericin B, fluconazole and caspofungin were also evaluated. Results: A total of 110 yeast strains isolated from urine and oral cavities were identified as C. albicans (51. 8%), C. krusei (25. 5%), C. glabrata (6. 4%) and other yeasts (16. 3%). No yeast species was isolated from blood samples. Our result showed that in 90% of the isolates, the range of secretion of Extracellular Enzymes was medium (2+) and high (3+), however only a few isolates were negative for this characteristic. All isolates were sensitive to caspofungin and fluconazole, whereas 54. 7% of isolates were resistant to amphotericin B. Conclusions: We found a marked increase in the incidence of non-albicans species (48. 2%) among Neutropenic Patients. Only a few strains failed to produce Extracellular Enzymes. Finally, in addition to fluconazole, caspofungin can be considered as the first line treatment against Candida species among Neutropenic Patients.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Gharaghani, Maral, REZAEI MATEHKOLAEI, ALI, ZAREI MAHMOUDABADI, ALI, & KEIKHAEI, BIJAN. (2016). The Frequency, Antifungal Susceptibility and Enzymatic Profiles of Candida Species Isolated from Neutropenic Patients. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 9(11), 0-0. SID. https://sid.ir/paper/317753/en

    Vancouver: Copy

    Gharaghani Maral, REZAEI MATEHKOLAEI ALI, ZAREI MAHMOUDABADI ALI, KEIKHAEI BIJAN. The Frequency, Antifungal Susceptibility and Enzymatic Profiles of Candida Species Isolated from Neutropenic Patients. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2016;9(11):0-0. Available from: https://sid.ir/paper/317753/en

    IEEE: Copy

    Maral Gharaghani, ALI REZAEI MATEHKOLAEI, ALI ZAREI MAHMOUDABADI, and BIJAN KEIKHAEI, “The Frequency, Antifungal Susceptibility and Enzymatic Profiles of Candida Species Isolated from Neutropenic Patients,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 9, no. 11, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/317753/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button