Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran

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ZANGI MARYAM; Bakhshandeh Azam; Mehrpouya Masoumeh; SHAHBAZI MAJID

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Journal Paper

Paper Information

Journal: Jundishapur Journal of Microbiology Year:2019 | Volume:12 | Issue:3 Page(s): 0-0

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Title

Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran

Author(s)

ZANGI MARYAM | Bakhshandeh Azam | Mehrpouya Masoumeh | SHAHBAZI MAJID | Issue Writer Certificate

Keywords

Hepatitis B Virus (HBV)

Hepatocellular Carcinoma (HCC)

Interleukin-13

Polymerase Chain Reaction (PCR)

Polymorphism

Abstract

Background: The most common primary cause of liver cancer is hepatocellular carcinoma (HCC). Cytokines as mediators have significant roles in immune and inflammatory responses. Interleukin-13 (IL-13) is a potent pleiotropic cytokine. Objectives: The aim of this study was to evaluate the association of IL-13/+110 gene Polymorphism in patients with chronic hepatitis B virus (HBV), one of the most important factors that lead to the development of HCC. Methods: DNA was extracted from peripheral blood cells of all 585 participants including 302 unrelated Hepatitis B surface antigen (HBS-Ag) positives and 283 healthy matched groups. The IL-13 gene Polymorphism (+ 110 A or G) was genotyped by SSP-PCR method and then genotype frequencies were checked by using the Pearson’ s chi-square test and/or Fisher exact test. Results: The frequencies of A/G genotype (CI = 1. 18-2. 34, OR = 1. 66, P = 0. 004) and A/A genotype (CI = 0. 95-3. 53, OR = 1. 84, P = 0. 071) were higher in the patients. Also, the frequency of A allele was remarkably higher in the HBV patients than control group (CI = 1. 09-1. 79, OR = 1. 84, P = 0. 071). Conclusions: High frequency of A allele in patients rather than control group suggested that A allele probably plays a role in augmenting susceptibility to HBV infection risk and high frequency of G allele in controls suggested this allele has a protective role in this disease.

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APA: Copy

ZANGI, MARYAM, Bakhshandeh, Azam, Mehrpouya, Masoumeh, & SHAHBAZI, MAJID. (2019). Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 12(3), 0-0. SID. https://sid.ir/paper/317837/en

Vancouver: Copy

ZANGI MARYAM, Bakhshandeh Azam, Mehrpouya Masoumeh, SHAHBAZI MAJID. Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2019;12(3):0-0. Available from: https://sid.ir/paper/317837/en

IEEE: Copy

MARYAM ZANGI, Azam Bakhshandeh, Masoumeh Mehrpouya, and MAJID SHAHBAZI, “Association of Interleukin 13/+110 Gene Polymorphism with Hepatitis B Virus Infection in Golestan Province, Northern Iran,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 12, no. 3, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/317837/en

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