Prevalence of Extended-Spectrum -Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran

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AZIZI MOHSEN; MORTAZAVI SEYED HAMIDREZA; Etemadi majed Misagh; GHEINI SIMIN; VAZIRI SIAVASH; ALVANDI AMIRHOOSHANG; KASHEF MAHSA; AHMADI KAMAL

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Journal: Jundishapur Journal of Microbiology Year:2017 | Volume:10 | Issue:12 Page(s): 0-0

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Title

Prevalence of Extended-Spectrum -Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran

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Keywords

Extended-Spectrum Beta-Lactamase (ESBL)

Antibiotic Resistance

Multidrug Resistance

Acinetobacter baumannii

Abstract

Background: Acinetobacter is an opportunistic bacterial pathogen with intrinsic and acquired resistance to many antibiotics. Objectives: This study aimed to determine the prevalence of extended-spectrum -lactamases (ESBLs) and Antibiotic Resistance patterns in A. baumannii isolated from clinical samples atImamReza hospital in Kermanshah, Iran, using phenotypic and genotypic methods. Methods: In this descriptive-analytical study, 80 Acinetobacter isolates obtained from clinical samples were confirmed using standard biochemical tests. After antibiotic susceptibility testing using disk diffusion method, the presence of ESBLs was detected using the combined disk test (CDT). The Polymerase chain reaction (PCR) method was employed to identify the frequency of blaTEM, blaCTX-M, and blaSHV genes using their specific primers. Results: Amongthe A. baumannii isolates, 62. 5% showed Multidrug Resistance (MDR). The highest rate of Antibiotic Resistance was to ceftriaxone (100%), followed by amikacin (96. 2%), and the lowest was to polymyxin B (13. 8%) and ampicillin/sulbactam (52. 8%). Fortythree (53. 8%) ESBL-producing isolates expressing SHV (n = 18, 41. 9%), TEM (n = 11, 25. 6%), and CTX-M (n = 3, 7%) genes were identified. Conclusions: This study revealed an increased prevalence of ESBL-encoding genes in A. baumannii isolates. The increased frequency of these genes may be due to overuse or inappropriate use of antibiotics in this region. To combat overuse and prevent further development of drug resistance in Kermanshah, Iran, more attention should be paid to prescribing practices for various antibiotics, including cephalosporins.

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APA: Copy

AZIZI, MOHSEN, MORTAZAVI, SEYED HAMIDREZA, Etemadi majed, Misagh, GHEINI, SIMIN, VAZIRI, SIAVASH, ALVANDI, AMIRHOOSHANG, KASHEF, MAHSA, & AHMADI, KAMAL. (2017). Prevalence of Extended-Spectrum -Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), 10(12), 0-0. SID. https://sid.ir/paper/317954/en

Vancouver: Copy

AZIZI MOHSEN, MORTAZAVI SEYED HAMIDREZA, Etemadi majed Misagh, GHEINI SIMIN, VAZIRI SIAVASH, ALVANDI AMIRHOOSHANG, KASHEF MAHSA, AHMADI KAMAL. Prevalence of Extended-Spectrum -Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran. JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM)[Internet]. 2017;10(12):0-0. Available from: https://sid.ir/paper/317954/en

IEEE: Copy

MOHSEN AZIZI, SEYED HAMIDREZA MORTAZAVI, Misagh Etemadi majed, SIMIN GHEINI, SIAVASH VAZIRI, AMIRHOOSHANG ALVANDI, MAHSA KASHEF, and KAMAL AHMADI, “Prevalence of Extended-Spectrum -Lactamases and Antibiotic Resistance Patterns in Acinetobacter baumannii Isolated from Clinical Samples in Kermanshah, Iran,” JUNDISHAPUR JOURNAL OF MICROBIOLOGY (JJM), vol. 10, no. 12, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/317954/en

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