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Information Journal Paper

Title

EFFECT OF SUPPLEMENTATION OF DIET WITH VITAMIN C ON INDUCTION AND CONSEQUENCES OF STREPTOZOTOCIN-DIABETES IN RATS

Pages

  12-18

Abstract

 OBJECTIVE: STREPTOZOTOCIN (STZ) destroys the beta cells of pancreas by generation of reactive oxygen species and vitamin C has documented antioxidant properties. This study was designed to evaluate the preventive effect of supplementation of DIET by vitamin C on induction of STZ-DIABETES and its effect on carbohydrate and lipid metabolism of diabetic rats.MATERIALS AND METHODS: Fifty male Wistar rats were divided randomly into nondiabetic (ND), diabetic (D), C1, C2 and C3 groups. The DIET of C1, C2 and C3 groups were supplemented with 2.5, 5 and 10 g/kg of vitamin C, respectively. Four days later all groups except ND, were made diabetic by IP injection of STZ and blood glucose was measured 72 h later to determine the severity of blood glucose elevation. Weight gain was measured weekly.21 days after induction of DIABETES Glycosylated hemoglobin (HbA1C), triglyceride (TG), total cholesterol (TC), HDL-C and LDL-C were measured or calculated in plasma of 6 diabetic rats in each groups that their glucose was more than 200 mg/dl after STZ injection.RESULTS: Vitamin C significantly prevented blood glucose elevation after STZ injection in group C2. Weight gain decreased in all diabetic groups. Increase of HbA1c could not be prevented by vitamin C in any groups. TC and LDL-C decreased and HDL% increased in group C3.CONCLUSION: We suggest that the amount of vitamin C consumption may have an important effect on STZ-DIABETES induction and it may be in agreement with opposite effects of free radicals on insulin receptor signaling. Furthermore, vitamin C may have some beneficial effects on lipid metabolism disorders of DIABETES.

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    APA: Copy

    FATEMI TABATABAEI, SEYED REZA, PAPAHN, AHMAD ALI, RAZI JALALI, MOHAMMAD, & JALILIAN, LIDA. (2011). EFFECT OF SUPPLEMENTATION OF DIET WITH VITAMIN C ON INDUCTION AND CONSEQUENCES OF STREPTOZOTOCIN-DIABETES IN RATS. IRANIAN JOURNAL OF DIABETES AND OBESITY, 3(1), 12-18. SID. https://sid.ir/paper/318117/en

    Vancouver: Copy

    FATEMI TABATABAEI SEYED REZA, PAPAHN AHMAD ALI, RAZI JALALI MOHAMMAD, JALILIAN LIDA. EFFECT OF SUPPLEMENTATION OF DIET WITH VITAMIN C ON INDUCTION AND CONSEQUENCES OF STREPTOZOTOCIN-DIABETES IN RATS. IRANIAN JOURNAL OF DIABETES AND OBESITY[Internet]. 2011;3(1):12-18. Available from: https://sid.ir/paper/318117/en

    IEEE: Copy

    SEYED REZA FATEMI TABATABAEI, AHMAD ALI PAPAHN, MOHAMMAD RAZI JALALI, and LIDA JALILIAN, “EFFECT OF SUPPLEMENTATION OF DIET WITH VITAMIN C ON INDUCTION AND CONSEQUENCES OF STREPTOZOTOCIN-DIABETES IN RATS,” IRANIAN JOURNAL OF DIABETES AND OBESITY, vol. 3, no. 1, pp. 12–18, 2011, [Online]. Available: https://sid.ir/paper/318117/en

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