IN VITRO ANTI-HIV-1 ACTIVITIES OF KAEMPFEROL AND KAEMPFEROL-7-OGLUCOSIDE ISOLATED FROM SECURIGERA SECURIDACA

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BEHBAHANI M.; SAYEDIPOUR S.; POURAZAR A.; SHANEHSAZZADEH M.

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Journal Paper

Paper Information

Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2014 | Volume:9 | Issue:6 Page(s): 463-469

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Title

IN VITRO ANTI-HIV-1 ACTIVITIES OF KAEMPFEROL AND KAEMPFEROL-7-OGLUCOSIDE ISOLATED FROM SECURIGERA SECURIDACA

Author(s)

BEHBAHANI M. | SAYEDIPOUR S. | POURAZAR A. | SHANEHSAZZADEH M. | Issue Writer Certificate

Keywords

HIV-1

ANTIVIRAL ACTIVITY

FLAVONOL

REAL TIME PCR ASSAY

Abstract

Previously, we reported that the kaempferol and kaempferol-7-O-glucoside isolated from Securigera securidaca showed potent anti-HSV activity. In the present study the anti-HIV-1 activities of kaempferol and kaempferol-7-O-glucoside are investigated at different concentrations (100, 50, 25 and 10 μg/ml) using HIV- 1 p24 Antigen kit. Real-time Polymerase chain reaction (RT-PCR) assay was also used for quantification of full range of virus load observed in treated and untreated cells. According to the results of RT- PCR, tested compounds at a concentration of 100 μg/ml exerted potent inhibitory effect. Time of drug addiction experiments demonstrated that these compounds exerted their inhibitory effects on the early stage of HIV infection. The results also showed potent anti-HIV-1 reverse transcriptase activity. ANTIVIRAL ACTIVITY of kaempferol-7-O-glucoside was more pronounced than that of kaempferol. These findings demonstrate that kaempferol-7-O-glucoside could be considered as a new potential drug candidate for the treatment of HIV infection which requires further assessments.

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APA: Copy

BEHBAHANI, M., SAYEDIPOUR, S., POURAZAR, A., & SHANEHSAZZADEH, M.. (2014). IN VITRO ANTI-HIV-1 ACTIVITIES OF KAEMPFEROL AND KAEMPFEROL-7-OGLUCOSIDE ISOLATED FROM SECURIGERA SECURIDACA. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 9(6), 463-469. SID. https://sid.ir/paper/318374/en

Vancouver: Copy

BEHBAHANI M., SAYEDIPOUR S., POURAZAR A., SHANEHSAZZADEH M.. IN VITRO ANTI-HIV-1 ACTIVITIES OF KAEMPFEROL AND KAEMPFEROL-7-OGLUCOSIDE ISOLATED FROM SECURIGERA SECURIDACA. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2014;9(6):463-469. Available from: https://sid.ir/paper/318374/en

IEEE: Copy

M. BEHBAHANI, S. SAYEDIPOUR, A. POURAZAR, and M. SHANEHSAZZADEH, “IN VITRO ANTI-HIV-1 ACTIVITIES OF KAEMPFEROL AND KAEMPFEROL-7-OGLUCOSIDE ISOLATED FROM SECURIGERA SECURIDACA,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 9, no. 6, pp. 463–469, 2014, [Online]. Available: https://sid.ir/paper/318374/en

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