مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

HYDRO-ALCOHOLIC EXTRACT OF RAPHANUS SATIVUS L. VAR NIGER ATTENUATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS VIA DECREASING TRANSFORMING GROWTH FACTOR β1 LEVEL

Pages

  429-435

Abstract

 PULMONARY FIBROSIS is a progressive disease of the lungs, which leads to death in human. It has been suggested that transforming growth factor beta 1 (TGF-b1) together with oxidative stress play a central role in the pathogenesis of the ailment. The objective of this study was to evaluate the possible curative effects of black radish, RAPHANUS SATIVUS L. VAR NIGER (RSN) on BLEOMYCINe (BLM) -induced PULMONARY FIBROSIS in a rat model. In this study, thirty-six male Wistar rats were divided into six groups, including: (I) positive (BLM) control group, (II) negative (normal saline) control group, (III) sham group (R. sativus extract 150 mg/kg), and (IV-VI) treatment groups. In order to induce PULMONARY FIBROSIS, four groups were treated with a single dose of BLM sulfate (7.5 U/kg) through intratracheal instillation. Treatment groups (IV-VI) received RSN extract (75, 150, and 300 mg/kg) orally a week before and two weeks after the administration of BLM. At the end of the treatment course, blood and lung tissue samples were taken and the measurement of TGF- b1 and histopathological examination of the lung tissues performed. The results showed that RSN, at 300 mg/kg dose, could significantly decrease the serum level of TGF-b1 and severity of the histological lesions as compared to the positive control group. The results of the current study indicate that the components present in the extract can remarkably prevent the aggravation of PULMONARY FIBROSIS via decreasing TGF-b1 level.

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    APA: Copy

    ASGHARI, MOHAMMAD HOSSEIN, HOBBENAGHI, RAHIM, NAZARIZADEH, ALI, & MIKAILI, PEYMAN. (2015). HYDRO-ALCOHOLIC EXTRACT OF RAPHANUS SATIVUS L. VAR NIGER ATTENUATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS VIA DECREASING TRANSFORMING GROWTH FACTOR β1 LEVEL. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 10(5), 429-435. SID. https://sid.ir/paper/318403/en

    Vancouver: Copy

    ASGHARI MOHAMMAD HOSSEIN, HOBBENAGHI RAHIM, NAZARIZADEH ALI, MIKAILI PEYMAN. HYDRO-ALCOHOLIC EXTRACT OF RAPHANUS SATIVUS L. VAR NIGER ATTENUATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS VIA DECREASING TRANSFORMING GROWTH FACTOR β1 LEVEL. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2015;10(5):429-435. Available from: https://sid.ir/paper/318403/en

    IEEE: Copy

    MOHAMMAD HOSSEIN ASGHARI, RAHIM HOBBENAGHI, ALI NAZARIZADEH, and PEYMAN MIKAILI, “HYDRO-ALCOHOLIC EXTRACT OF RAPHANUS SATIVUS L. VAR NIGER ATTENUATES BLEOMYCIN-INDUCED PULMONARY FIBROSIS VIA DECREASING TRANSFORMING GROWTH FACTOR β1 LEVEL,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 10, no. 5, pp. 429–435, 2015, [Online]. Available: https://sid.ir/paper/318403/en

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