EFFECTS OF LONG TERM ADMINISTRATION OF TESTOSTERONE AND ESTRADIOL ON SPATIAL MEMORY IN RATS

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MOHAMMADI FARANI AHMAD; HAGHIGHI ARASH; GHAZVINEH MILAD

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Journal Paper

Paper Information

Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2015 | Volume:10 | Issue:5 Page(s): 407-418

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Title

EFFECTS OF LONG TERM ADMINISTRATION OF TESTOSTERONE AND ESTRADIOL ON SPATIAL MEMORY IN RATS

Author(s)

MOHAMMADI FARANI AHMAD | HAGHIGHI ARASH | GHAZVINEH MILAD | Issue Writer Certificate

Keywords

SPATIAL REFERENCE MEMORY

TESTOSTERONE

ESTRADIOL

ACETYLCHOLINESTERASE

MORRIS WATER MAZE

HIPPOCAMPUS

Abstract

There are many discrepancies around the effect of sex hormones on spatial learning and memory in rodents. The aim of the present study was to investigate the effects of chronic administration of ESTRADIOL (ES) and TESTOSTERONE (TES) on spatial memory in adult castrated male rats. Cholinesterase activity of the HIPPOCAMPUS in treated animals was also measured to seek if hormonal treatment can change the ACETYLCHOLINESTERASE (AChE) activity in this region. Six groups of castrated male rats received different doses of ES valerate (1, 4, 10 mg/kg, by subcutaneous, sc) and TES enanthate (10, 20, 40 mg/kg, sc) in weekly injection intervals for 6 weeks. MORRIS WATER MAZE (MWM) was used to assess the SPATIAL REFERENCE MEMORY of the rats. The specific activity of AChE in the HIPPOCAMPUS was also measured. The treatment duration and the dose quantity of ES had significant (P<0.001 and P=0.048, respectively) effect on the learning ability in the rats. For TES treated rats, treatment duration showed a significant effect (P<0.001) on learning performance of the rats. The activity of AChE compared to the control group was significantly increased in ES treated rats in a dose dependent manner and it was decreased in the group that received the highest dose of TES. Our results showed that chronic high dose of ES decreased the learning ability of male castrated rats in a reference memory version of MWM test. This can be explained by the decreased AChE activity in the HIPPOCAMPUS.

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APA: Copy

MOHAMMADI FARANI, AHMAD, HAGHIGHI, ARASH, & GHAZVINEH, MILAD. (2015). EFFECTS OF LONG TERM ADMINISTRATION OF TESTOSTERONE AND ESTRADIOL ON SPATIAL MEMORY IN RATS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 10(5), 407-418. SID. https://sid.ir/paper/318405/en

Vancouver: Copy

MOHAMMADI FARANI AHMAD, HAGHIGHI ARASH, GHAZVINEH MILAD. EFFECTS OF LONG TERM ADMINISTRATION OF TESTOSTERONE AND ESTRADIOL ON SPATIAL MEMORY IN RATS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2015;10(5):407-418. Available from: https://sid.ir/paper/318405/en

IEEE: Copy

AHMAD MOHAMMADI FARANI, ARASH HAGHIGHI, and MILAD GHAZVINEH, “EFFECTS OF LONG TERM ADMINISTRATION OF TESTOSTERONE AND ESTRADIOL ON SPATIAL MEMORY IN RATS,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 10, no. 5, pp. 407–418, 2015, [Online]. Available: https://sid.ir/paper/318405/en

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