A COMPARATIVE HISTOLOGICAL STUDY ON THE SKIN OCCLUSION PERFORMANCE OF A CREAM MADE OF SOLID LIPID NANOPARTICLES AND VASELINE

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HAMISHEHKAR HAMED; SAME SAEIDEH; ADIBKIA KHOSRO; ZARZA KAMYAR; SHOKRI JAVAD; TAGHAEE MEHRAN; KOUHSOLTANI MARYAM

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Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2015 | Volume:10 | Issue:5 Page(s): 378-387

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Title

A COMPARATIVE HISTOLOGICAL STUDY ON THE SKIN OCCLUSION PERFORMANCE OF A CREAM MADE OF SOLID LIPID NANOPARTICLES AND VASELINE

Author(s)

Keywords

SOLID LIPID NANOPARTICLES

TOPICAL OCCLUSIVE

COSMECEUTICS

SKIN MOISTURIZER

Abstract

The water content of the epidermis is a main factor in maintaining skin smoothness and elasticity and preventing skin dryness. Occlusive products can greatly affect skin hydration by forming a barrier on the skin following the topical administration of oil-based formulations. These products repair the skin barrier by restoring the skin lipids as well. SOLID LIPID NANOPARTICLES (SLNs) have recently been introduced as a novel carrier with several benefits in pharmaceutics and COSMECEUTICS. It has been suggested that SLNs may have an occlusive effect following topical application. In this study, the occlusion effects of lipidic particles in different size ranges were investigated in vitro, ex vivo, and in vivo, and the results were compared with the positive (vaseline) and negative (blank) controls. Although larger lipidic particles showed better occlusion properties than nanoparticles in vitro, but ex vivo experiments confirmed the benefits of nanoparticles (almost 30% higher occlusion factor for particles in the range of 170 nm than ones in the range of 600 and 1800 nm). The superiority of SLN formulation to Vaseline as a positive reference was confirmed by the in vivo study. SLN formulation resulted in much thicker stratum corneum than Vaseline. It was indicated that in vitro and ex vivo study methods may not be a good reflective of the in vivo method for determining the occlusive properties of nanoparticulate systems. It was concluded that formulations containing SLNs can be used as efficient SKIN MOISTURIZER products.

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APA: Copy

HAMISHEHKAR, HAMED, SAME, SAEIDEH, ADIBKIA, KHOSRO, ZARZA, KAMYAR, SHOKRI, JAVAD, TAGHAEE, MEHRAN, & KOUHSOLTANI, MARYAM. (2015). A COMPARATIVE HISTOLOGICAL STUDY ON THE SKIN OCCLUSION PERFORMANCE OF A CREAM MADE OF SOLID LIPID NANOPARTICLES AND VASELINE. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 10(5), 378-387. SID. https://sid.ir/paper/318406/en

Vancouver: Copy

HAMISHEHKAR HAMED, SAME SAEIDEH, ADIBKIA KHOSRO, ZARZA KAMYAR, SHOKRI JAVAD, TAGHAEE MEHRAN, KOUHSOLTANI MARYAM. A COMPARATIVE HISTOLOGICAL STUDY ON THE SKIN OCCLUSION PERFORMANCE OF A CREAM MADE OF SOLID LIPID NANOPARTICLES AND VASELINE. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2015;10(5):378-387. Available from: https://sid.ir/paper/318406/en

IEEE: Copy

HAMED HAMISHEHKAR, SAEIDEH SAME, KHOSRO ADIBKIA, KAMYAR ZARZA, JAVAD SHOKRI, MEHRAN TAGHAEE, and MARYAM KOUHSOLTANI, “A COMPARATIVE HISTOLOGICAL STUDY ON THE SKIN OCCLUSION PERFORMANCE OF A CREAM MADE OF SOLID LIPID NANOPARTICLES AND VASELINE,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 10, no. 5, pp. 378–387, 2015, [Online]. Available: https://sid.ir/paper/318406/en

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