SYNTHESIS AND CYTOTOXIC EVALUATION OF SOME NEW 3-(2-(2-PHENYLTHIAZOL- 4-YL) ETHYL)-QUINAZOLIN-4(3H) ONE DERIVATIVES WITH POTENTIAL ANTICANCER EFFECTS

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HOSSEINZADEH LEILA; ALIABADI ALIREZA; RAHNAMA MOHSEN; MIRMOHAMMAD SADEGHI HAMID; RAHMANI KHAJOUEI MARZIEH

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Paper Information

Journal: RESEARCH IN PHARMACEUTICAL SCIENCES (RPS) Year:2017 | Volume:12 | Issue:4 Page(s): 290-298

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Title

SYNTHESIS AND CYTOTOXIC EVALUATION OF SOME NEW 3-(2-(2-PHENYLTHIAZOL- 4-YL) ETHYL)-QUINAZOLIN-4(3H) ONE DERIVATIVES WITH POTENTIAL ANTICANCER EFFECTS

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Keywords

QUINAZOLINONE

THIAZOLE

CYTOTOXIC

Abstract

QUINAZOLINONEs are a group of heterocyclic compounds that have important biological activities such as CYTOTOXICity, anti-bacterial, and anti-fungal effects. THIAZOLE-containing compounds have also many biological effects including antitumor, antibacterial, anti-inflammatory, and analgesic activities. Due to significant CYTOTOXIC effects of both quinazoline and THIAZOLE derivatives, in this work a group of QUINAZOLINONE-thiazol hybrids were prepared and their CYTOTOXIC effects on three cell lines were evaluated using MTT assay. CompoundsA3, A2, B4, and A1 showed highest CYTOTOXIC activities against PC3 cell line. CompoundsA3, A5, and A2 were most active against MCF-7 and A3, A5, and A6 showed good CYTOTOXIC effect on HT-29 cell line. According to the results, A3 efficiently inhibited all cell growth tested in a dose dependent manner. The IC50 of A3 was 10 M, 10 mM, and 12 mM on PC3, MCF-7, and HT-29 cells, respectively.

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APA: Copy

HOSSEINZADEH, LEILA, ALIABADI, ALIREZA, RAHNAMA, MOHSEN, MIRMOHAMMAD SADEGHI, HAMID, & RAHMANI KHAJOUEI, MARZIEH. (2017). SYNTHESIS AND CYTOTOXIC EVALUATION OF SOME NEW 3-(2-(2-PHENYLTHIAZOL- 4-YL) ETHYL)-QUINAZOLIN-4(3H) ONE DERIVATIVES WITH POTENTIAL ANTICANCER EFFECTS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), 12(4), 290-298. SID. https://sid.ir/paper/318466/en

Vancouver: Copy

HOSSEINZADEH LEILA, ALIABADI ALIREZA, RAHNAMA MOHSEN, MIRMOHAMMAD SADEGHI HAMID, RAHMANI KHAJOUEI MARZIEH. SYNTHESIS AND CYTOTOXIC EVALUATION OF SOME NEW 3-(2-(2-PHENYLTHIAZOL- 4-YL) ETHYL)-QUINAZOLIN-4(3H) ONE DERIVATIVES WITH POTENTIAL ANTICANCER EFFECTS. RESEARCH IN PHARMACEUTICAL SCIENCES (RPS)[Internet]. 2017;12(4):290-298. Available from: https://sid.ir/paper/318466/en

IEEE: Copy

LEILA HOSSEINZADEH, ALIREZA ALIABADI, MOHSEN RAHNAMA, HAMID MIRMOHAMMAD SADEGHI, and MARZIEH RAHMANI KHAJOUEI, “SYNTHESIS AND CYTOTOXIC EVALUATION OF SOME NEW 3-(2-(2-PHENYLTHIAZOL- 4-YL) ETHYL)-QUINAZOLIN-4(3H) ONE DERIVATIVES WITH POTENTIAL ANTICANCER EFFECTS,” RESEARCH IN PHARMACEUTICAL SCIENCES (RPS), vol. 12, no. 4, pp. 290–298, 2017, [Online]. Available: https://sid.ir/paper/318466/en

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