THE HEALING EFFECT OF TEUCRIUM POLIUM IN ACETIC ACIDINDUCED ULCERATIVE COLITIS IN THE DOG AS AN ANIMAL MODEL

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MEHRABANI DAVOOD; BAHRAMI FARANAK; HOSSEINI SEYED VAHID; ASHRAF MOHAMMAD JAVAD; TANIDEH NADER; REZAIANZADEH ABBAS; AMINI MASOUD; AMINI AFSHIN

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Journal: MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD) Year:2012 | Volume:4 | Issue:1 Page(s): 40-47

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Title

THE HEALING EFFECT OF TEUCRIUM POLIUM IN ACETIC ACIDINDUCED ULCERATIVE COLITIS IN THE DOG AS AN ANIMAL MODEL

Author(s)

Keywords

ULCERATIVE COLITIS

ACETIC ACID

TEUCRIUM POLIUM

TREATMENT

DOG

Abstract

Back Ground: Inflammatory bowel diseases (IBD), which include ULCERATIVE COLITIS (UC) and Crohn’s disease (CD), are debilitating and chronic disorders with unpredictable courses and complicated TREATMENT measures. Therefore, an efficient TREATMENT protocol seems necessary as therapeutic prophylaxis for these disorders. This study aims to determine the healing effect of TEUCRIUM POLIUM (T. polium) in ACETIC ACID-induced UC in an experimental DOG model.METHODS: From September to December 2010, eight male (20-25 kg) crossbred DOGs were used for induction of UC by 6% ACETIC ACID, transrectally. After one week, three biopsies (10, 20 and 30 cm proximal to the anal verge) were taken from the colon of each animal for histological studies. In the presence of UC, 400 mg/kg/day of T. poliumextract was administered orally and transrectally (via enema) for 30 days in six of the DOGs. The remaining two DOGs were used as controls and did not receiveT. polium. Multiple biopsies were taken 7, 14, and 30 days after discontinuation of T. poliumin the same manner as before TREATMENT.RESULTS: After administration of ACETIC ACID, we noted the presence of multiple ulcers, diffuse inflammation, PMN infiltration in the lamina propria, glandular destruction and goblet cell depletion. TREATMENT with T. polium restored the colonic architecture with an increased number of healthy cells and a reduction in inflammatory cells. Damage of the surface epithelial cells and mucosal layer of the lumen were reversed, which lead to faster ulcer healing.CONCLUSION: T. poliummay be a TREATMENT choice for UC and can broaden the current therapy options for UC.

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APA: Copy

MEHRABANI, DAVOOD, BAHRAMI, FARANAK, HOSSEINI, SEYED VAHID, ASHRAF, MOHAMMAD JAVAD, TANIDEH, NADER, REZAIANZADEH, ABBAS, AMINI, MASOUD, & AMINI, AFSHIN. (2012). THE HEALING EFFECT OF TEUCRIUM POLIUM IN ACETIC ACIDINDUCED ULCERATIVE COLITIS IN THE DOG AS AN ANIMAL MODEL. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 4(1), 40-47. SID. https://sid.ir/paper/319075/en

Vancouver: Copy

MEHRABANI DAVOOD, BAHRAMI FARANAK, HOSSEINI SEYED VAHID, ASHRAF MOHAMMAD JAVAD, TANIDEH NADER, REZAIANZADEH ABBAS, AMINI MASOUD, AMINI AFSHIN. THE HEALING EFFECT OF TEUCRIUM POLIUM IN ACETIC ACIDINDUCED ULCERATIVE COLITIS IN THE DOG AS AN ANIMAL MODEL. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)[Internet]. 2012;4(1):40-47. Available from: https://sid.ir/paper/319075/en

IEEE: Copy

DAVOOD MEHRABANI, FARANAK BAHRAMI, SEYED VAHID HOSSEINI, MOHAMMAD JAVAD ASHRAF, NADER TANIDEH, ABBAS REZAIANZADEH, MASOUD AMINI, and AFSHIN AMINI, “THE HEALING EFFECT OF TEUCRIUM POLIUM IN ACETIC ACIDINDUCED ULCERATIVE COLITIS IN THE DOG AS AN ANIMAL MODEL,” MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), vol. 4, no. 1, pp. 40–47, 2012, [Online]. Available: https://sid.ir/paper/319075/en

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