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Information Journal Paper

Title

MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY OF PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA IN KIT NEGATIVE GASTROINTESTINAL STROMAL TUMORS, THE FIRST REPORT FROM IRAN

Pages

  248-253

Keywords

Abstract

 INTRODUCTION: Gastrointestinal STROMAL TUMORS (GISTs) are potentially malignant tumors, however their behavior and response to treatment is dependent on the type of mutation and immunohistochemical expression of antigens. It is recommended to perform routine molecular and immunohistochemical tests in KIT and platelet derived growth factor receptor alpha (PDGFRA) molecules for making decision regarding targeted therapy and prediction of the behavior of the tumor.Objectives: There has been no study from IRAN regarding the PDGFRA mutational analysis in GISTs. In this study, for the first time from IRAN, we performed immunohistochemical and molecular analysis of PDGFRA: molecule on GISTs.METHODS: In a cross-sectional study during 7 years (2008-2014) on 50 untreated non-recurrent non-metastatic newly diagnosed GISTs, molecular analysis and immunohistochemical staining for PDGFRA were performed and findings were compared with different clinicopathological characteristics.RESULTS: During the 7 years, 50 cases of GISTs according to the above mentioned criteria were found.17 cases were negative for KIT mutation. Of them, 15 (30%) were positive for either exon 12 or 18 mutation of PDGFRA. These cases showed more epithelioid morphology and the number of mitotic figures were lower than PDFRA negative GISTs. Also according to the criteria for risk assessment, it seems that PDGFRA mutant GISTs are rarely in the high risk category.CONCLUSION: PDGFRA mutant GISTs are common in IRANian population and it is recommended to perform mutation analysis for PDGFRA in every GIST with wild type KIT and epithelioid morphology.

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    APA: Copy

    GERAMIZADEH, BITA, JOWKAR, ZAHRA, & MOUSAVI, SEYED JAVAD. (2016). MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY OF PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA IN KIT NEGATIVE GASTROINTESTINAL STROMAL TUMORS, THE FIRST REPORT FROM IRAN. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), 8(3), 248-253. SID. https://sid.ir/paper/319138/en

    Vancouver: Copy

    GERAMIZADEH BITA, JOWKAR ZAHRA, MOUSAVI SEYED JAVAD. MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY OF PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA IN KIT NEGATIVE GASTROINTESTINAL STROMAL TUMORS, THE FIRST REPORT FROM IRAN. MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD)[Internet]. 2016;8(3):248-253. Available from: https://sid.ir/paper/319138/en

    IEEE: Copy

    BITA GERAMIZADEH, ZAHRA JOWKAR, and SEYED JAVAD MOUSAVI, “MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY OF PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA IN KIT NEGATIVE GASTROINTESTINAL STROMAL TUMORS, THE FIRST REPORT FROM IRAN,” MIDDLE EAST JOURNAL OF DIGESTIVE DISEASES (MEJDD), vol. 8, no. 3, pp. 248–253, 2016, [Online]. Available: https://sid.ir/paper/319138/en

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