Performance and Predictive Value of First Trimester Screening Markers for Down Syndrome in Iranian Pregnancies

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HEIDARI REZA; Akbariqomi Mostafa; Motevaseli Elaheh; OMRANI MIR DAVOOD; Kooshki Hamid; SHAMSHIRI AHMAD REZA; Shafei Shilan; Absalan Moloud; Mazlomi Mohammad Ali; SALEH GARGARI SORAYA; Tavoosidana Gholamreza

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Journal: JOURNAL OF FAMILY AND REPRODUCTIVE HEALTH Year:2018 | Volume:12 | Issue:3 Page(s): 121-128

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Title

Performance and Predictive Value of First Trimester Screening Markers for Down Syndrome in Iranian Pregnancies

Author(s)

Keywords

Down Syndrome

First Trimester Screening

Serum Marker

Sonographic Markers

Abstract

Objective: To investigate the performance of first trimester Down Syndrome (DS) screening markers in Iranian pregnancies. Although sonographic and Serum Markers are currently recommended for the First Trimester Screening of Down Syndrome, the screening performance of the markers depends on the race and ethnicity. Materials and methods: A retrospective case-control study using First Trimester Screening results recorded with the prenatal diagnostic multi-centers in Iran. A total of 6, 384 pregnant women were examined from March 2012 to February 2017. Totally 100 Down Syndrome cases and 266 matched controls were selected and the maternal characteristics, sonographic and biochemical screening data were collected. Statistical analysis was performed using logistic regression and descriptive statistics. A decision tree model was designed using the chi-squared automatic interaction detection method based on Serum Markers. Results: For screening of DS pregnancies, PAPP-A (cut-off 0. 795 MoM) yielded the highest sensitivity (86%) and NB marker presented highest specificity (96. 24%). combination of the biochemical markers PAPP-A and β-hCG (cut-off: 1. 55 MoM) showed the highest sensitivity over other combined markers. The decision-tree model based on Serum Markers improved (91% DR For a 5% FPR) First Trimester Screening performance. Conclusion: The novel decision-tree model base on Serum Markers revealed a better predictive value to achieve high sensitivity and specificity of first trimester Down Syndrome screening in Iranian population.

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Factors predicting a positive pregnancy screening test at first trimester

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APA: Copy

HEIDARI, REZA, Akbariqomi, Mostafa, Motevaseli, Elaheh, OMRANI, MIR DAVOOD, Kooshki, Hamid, SHAMSHIRI, AHMAD REZA, Shafei, Shilan, Absalan, Moloud, Mazlomi, Mohammad Ali, SALEH GARGARI, SORAYA, & Tavoosidana, Gholamreza. (2018). Performance and Predictive Value of First Trimester Screening Markers for Down Syndrome in Iranian Pregnancies. JOURNAL OF FAMILY AND REPRODUCTIVE HEALTH, 12(3), 121-128. SID. https://sid.ir/paper/320937/en

Vancouver: Copy

HEIDARI REZA, Akbariqomi Mostafa, Motevaseli Elaheh, OMRANI MIR DAVOOD, Kooshki Hamid, SHAMSHIRI AHMAD REZA, Shafei Shilan, Absalan Moloud, Mazlomi Mohammad Ali, SALEH GARGARI SORAYA, Tavoosidana Gholamreza. Performance and Predictive Value of First Trimester Screening Markers for Down Syndrome in Iranian Pregnancies. JOURNAL OF FAMILY AND REPRODUCTIVE HEALTH[Internet]. 2018;12(3):121-128. Available from: https://sid.ir/paper/320937/en

IEEE: Copy

REZA HEIDARI, Mostafa Akbariqomi, Elaheh Motevaseli, MIR DAVOOD OMRANI, Hamid Kooshki, AHMAD REZA SHAMSHIRI, Shilan Shafei, Moloud Absalan, Mohammad Ali Mazlomi, SORAYA SALEH GARGARI, and Gholamreza Tavoosidana, “Performance and Predictive Value of First Trimester Screening Markers for Down Syndrome in Iranian Pregnancies,” JOURNAL OF FAMILY AND REPRODUCTIVE HEALTH, vol. 12, no. 3, pp. 121–128, 2018, [Online]. Available: https://sid.ir/paper/320937/en

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