مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

CYTOTOXIC EFFECT OF LUTEOLIN ON HUMAN COLORECTAL CANCER CELL LINE (HCT-15): CRUCIAL INVOLVEMENT OF REACTIVE OXYGEN SPECIES

Pages

  175-180

Abstract

 Background: Colorectal cancer, a major health concern worldwide, is the third most common form of cancer and second leading cause of cancer-related deaths. The flavonoids are naturally occurring diphenylpropanoids ubiquitous in plant foods and important components of the human diet. LUTEOLIN, a bioflavonoid, possesses many beneficial effects including antioxidant, anti-inflammatory, anti-allergic activities.Methods: We used the HCT-15 colon adenocarcinoma cell line in this study. Cells were treated with LUTEOLIN (100 mM).Results: Membrane damage markers such as alkaline phosphatase and lactate dehydrogenase were analyzed in a time-dependent manner. LUTEOLIN increased reactive oxygen species in a time-dependent manner. DNA damage, a hallmark of apoptosis, was induced by LUTEOLIN as analyzed by agarose gel electrophoresis.Conclusion: LUTEOLIN acts as a potential cytotoxic agent that can be used to treat colorectal cancer.

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    APA: Copy

    PANDURANGAN, ASHOK KUMAR, & GANAPASAM, SUDHANDIRAN. (2013). CYTOTOXIC EFFECT OF LUTEOLIN ON HUMAN COLORECTAL CANCER CELL LINE (HCT-15): CRUCIAL INVOLVEMENT OF REACTIVE OXYGEN SPECIES. MIDDLE EAST JOURNAL OF CANCER, 4(4), 175-180. SID. https://sid.ir/paper/321068/en

    Vancouver: Copy

    PANDURANGAN ASHOK KUMAR, GANAPASAM SUDHANDIRAN. CYTOTOXIC EFFECT OF LUTEOLIN ON HUMAN COLORECTAL CANCER CELL LINE (HCT-15): CRUCIAL INVOLVEMENT OF REACTIVE OXYGEN SPECIES. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2013;4(4):175-180. Available from: https://sid.ir/paper/321068/en

    IEEE: Copy

    ASHOK KUMAR PANDURANGAN, and SUDHANDIRAN GANAPASAM, “CYTOTOXIC EFFECT OF LUTEOLIN ON HUMAN COLORECTAL CANCER CELL LINE (HCT-15): CRUCIAL INVOLVEMENT OF REACTIVE OXYGEN SPECIES,” MIDDLE EAST JOURNAL OF CANCER, vol. 4, no. 4, pp. 175–180, 2013, [Online]. Available: https://sid.ir/paper/321068/en

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