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Information Journal Paper

Title

DECREASED SERUM LEVEL OF INTERLEUKIN-19 IN IRANIAN PATIENTS WITH BREAST CANCER

Pages

  203-209

Abstract

 Background: INTERLEUKIN-19, a member of the interleukin-10 family of cytokines, contributes to BREAST CANCER pathogenesis. High INTERLEUKIN-19 expression in breast tumor tissues is associated with poor clinical outcome. This study aimed to assess the changes in SERUM LEVEL of INTERLEUKIN-19 in BREAST CANCER patients in comparison with normal women and its association with the clinicopathological parameters of this disease.Methods: Enzyme-linked immunosorbent assay was used to analyze SERUM LEVELs of INTERLEUKIN-19 in 116 women with BREAST CANCER before chemotherapy or radiotherapy, and in 60 healthy age-matched women without any acute or chronic diseases or family history of cancer.Results: There were significantly lower serum INTERLEUKIN-19 levels in BREAST CANCER patients (median: 27.3 pg/ml; range: 10.5-2443.6 pg/ml) compared to healthy controls (median: 35.1 pg/ml; range: 10.9-13676.6 pg/ml; P<0.01). Compared to the healthy control group, the decrease in serum INTERLEUKIN-19 concentration was seen in all BREAST CANCER stages. However the decrease was only significant for stage III (P=0.02). We found no significant association between serum INTERLEUKIN-19 levels and stage, grade, lymph node involvement or other clinicopathological variables of the disease. However, when compared to the healthy control group, we found significantly decreased serum INTERLEUKIN-19 levels in patients with involved lymph nodes (P<0.01) or tumor size greater than 2 cm (P=0.01).Conclusion: There were significantly decreased INTERLEUKIN-19 levels in BREAST CANCER patients compared to the healthy control group. We observed no association between serum INTERLEUKIN-19 levels and clinicopathological parameters in BREAST CANCER patients.

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    APA: Copy

    MEHDIPOUR, FERESHTEH, MALEKZADEH, MAHYAR, TALEI, ABDOLRASOUL, & GHADERI, ABBAS. (2015). DECREASED SERUM LEVEL OF INTERLEUKIN-19 IN IRANIAN PATIENTS WITH BREAST CANCER. MIDDLE EAST JOURNAL OF CANCER, 6(4), 203-209. SID. https://sid.ir/paper/321142/en

    Vancouver: Copy

    MEHDIPOUR FERESHTEH, MALEKZADEH MAHYAR, TALEI ABDOLRASOUL, GHADERI ABBAS. DECREASED SERUM LEVEL OF INTERLEUKIN-19 IN IRANIAN PATIENTS WITH BREAST CANCER. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2015;6(4):203-209. Available from: https://sid.ir/paper/321142/en

    IEEE: Copy

    FERESHTEH MEHDIPOUR, MAHYAR MALEKZADEH, ABDOLRASOUL TALEI, and ABBAS GHADERI, “DECREASED SERUM LEVEL OF INTERLEUKIN-19 IN IRANIAN PATIENTS WITH BREAST CANCER,” MIDDLE EAST JOURNAL OF CANCER, vol. 6, no. 4, pp. 203–209, 2015, [Online]. Available: https://sid.ir/paper/321142/en

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