EVALUATION OF AN IMMUNOMODULATOR DRUG AS A RADIOPROTECTANT ON HUMAN PERIPHERAL BLOOD LYMPHOCYTESIN VITRO

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SATTARPOUR ZAHRA; BARADARAN BEHZAD; FARAJOLLAHI ALIREZA; ASGHARI JAFARABADI MOHAMMAD; KHAZEH VAHID; PIRAYESH ISLAMIAN JALIL

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Journal: MIDDLE EAST JOURNAL OF CANCER Year:2018 | Volume:9 | Issue:1 Page(s): 35-40

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Title

EVALUATION OF AN IMMUNOMODULATOR DRUG AS A RADIOPROTECTANT ON HUMAN PERIPHERAL BLOOD LYMPHOCYTESIN VITRO

Author(s)

Keywords

IMMUNOMODULATOR DRUG (IMOD™)

RADIOPROTECTANT

LYMPHOCYTE

MICRONUCLEI ASSAY

APOPTOSIS

Abstract

Background: IMOD™, a selenium enriched extract of the plants Tan acetum vulgare, Urtica dioica, and Rosa canina, has an excellent effect on oxidative stress. In this study, we investigated the radio protective effects of this immunomodulatory drug on human peripheral blood LYMPHOCYTEs.Methods: Peripheral blood samples obtained from venipuncture of the brachial vein were treated with IMOD™ (5, 10, 15, 20 ml) for 30 min and Cobalt 60 γ-rays (0.25, 0.5, 1, 2 Gy) as the test groups and cultured with the control. We used the MICRONUCLEI ASSAY, cell death detection, and cell toxicity assay to analyze the treatment effects.Results: The frequency of micronuclei were 1.66 (0 Gy), 5.33 (0.25 Gy), 9.67 (0.5 Gy), 17.67 (1 Gy), and 23.67 (2 Gy) in the irradiated LYMPHOCYTEs (P<0.001). The percentage of micronuclei frequency reduced to 20%, 26.83%, 37.68%, 16%, and 20.47% with IMOD™. APOPTOSIS and necrosis decreased significantly in the IMOD™ treated groups (P<0.05).Conclusion: IMOD™ may protect these cells against ionizing radiation.

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APA: Copy

SATTARPOUR, ZAHRA, BARADARAN, BEHZAD, FARAJOLLAHI, ALIREZA, ASGHARI JAFARABADI, MOHAMMAD, KHAZEH, VAHID, & PIRAYESH ISLAMIAN, JALIL. (2018). EVALUATION OF AN IMMUNOMODULATOR DRUG AS A RADIOPROTECTANT ON HUMAN PERIPHERAL BLOOD LYMPHOCYTESIN VITRO. MIDDLE EAST JOURNAL OF CANCER, 9(1), 35-40. SID. https://sid.ir/paper/321195/en

Vancouver: Copy

SATTARPOUR ZAHRA, BARADARAN BEHZAD, FARAJOLLAHI ALIREZA, ASGHARI JAFARABADI MOHAMMAD, KHAZEH VAHID, PIRAYESH ISLAMIAN JALIL. EVALUATION OF AN IMMUNOMODULATOR DRUG AS A RADIOPROTECTANT ON HUMAN PERIPHERAL BLOOD LYMPHOCYTESIN VITRO. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2018;9(1):35-40. Available from: https://sid.ir/paper/321195/en

IEEE: Copy

ZAHRA SATTARPOUR, BEHZAD BARADARAN, ALIREZA FARAJOLLAHI, MOHAMMAD ASGHARI JAFARABADI, VAHID KHAZEH, and JALIL PIRAYESH ISLAMIAN, “EVALUATION OF AN IMMUNOMODULATOR DRUG AS A RADIOPROTECTANT ON HUMAN PERIPHERAL BLOOD LYMPHOCYTESIN VITRO,” MIDDLE EAST JOURNAL OF CANCER, vol. 9, no. 1, pp. 35–40, 2018, [Online]. Available: https://sid.ir/paper/321195/en

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