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Information Journal Paper

Title

EVALUATION OF AN IMMUNOMODULATOR DRUG AS A RADIOPROTECTANT ON HUMAN PERIPHERAL BLOOD LYMPHOCYTESIN VITRO

Pages

  35-40

Keywords

IMMUNOMODULATOR DRUG (IMOD™) 

Abstract

 Background: IMOD™, a selenium enriched extract of the plants Tan acetum vulgare, Urtica dioica, and Rosa canina, has an excellent effect on oxidative stress. In this study, we investigated the radio protective effects of this immunomodulatory drug on human peripheral blood LYMPHOCYTEs.Methods: Peripheral blood samples obtained from venipuncture of the brachial vein were treated with IMOD™ (5, 10, 15, 20 ml) for 30 min and Cobalt 60 γ-rays (0.25, 0.5, 1, 2 Gy) as the test groups and cultured with the control. We used the MICRONUCLEI ASSAY, cell death detection, and cell toxicity assay to analyze the treatment effects.Results: The frequency of micronuclei were 1.66 (0 Gy), 5.33 (0.25 Gy), 9.67 (0.5 Gy), 17.67 (1 Gy), and 23.67 (2 Gy) in the irradiated LYMPHOCYTEs (P<0.001). The percentage of micronuclei frequency reduced to 20%, 26.83%, 37.68%, 16%, and 20.47% with IMOD™. APOPTOSIS and necrosis decreased significantly in the IMOD™ treated groups (P<0.05).Conclusion: IMOD™ may protect these cells against ionizing radiation.

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    APA: Copy

    SATTARPOUR, ZAHRA, BARADARAN, BEHZAD, FARAJOLLAHI, ALIREZA, ASGHARI JAFARABADI, MOHAMMAD, KHAZEH, VAHID, & PIRAYESH ISLAMIAN, JALIL. (2018). EVALUATION OF AN IMMUNOMODULATOR DRUG AS A RADIOPROTECTANT ON HUMAN PERIPHERAL BLOOD LYMPHOCYTESIN VITRO. MIDDLE EAST JOURNAL OF CANCER, 9(1), 35-40. SID. https://sid.ir/paper/321195/en

    Vancouver: Copy

    SATTARPOUR ZAHRA, BARADARAN BEHZAD, FARAJOLLAHI ALIREZA, ASGHARI JAFARABADI MOHAMMAD, KHAZEH VAHID, PIRAYESH ISLAMIAN JALIL. EVALUATION OF AN IMMUNOMODULATOR DRUG AS A RADIOPROTECTANT ON HUMAN PERIPHERAL BLOOD LYMPHOCYTESIN VITRO. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2018;9(1):35-40. Available from: https://sid.ir/paper/321195/en

    IEEE: Copy

    ZAHRA SATTARPOUR, BEHZAD BARADARAN, ALIREZA FARAJOLLAHI, MOHAMMAD ASGHARI JAFARABADI, VAHID KHAZEH, and JALIL PIRAYESH ISLAMIAN, “EVALUATION OF AN IMMUNOMODULATOR DRUG AS A RADIOPROTECTANT ON HUMAN PERIPHERAL BLOOD LYMPHOCYTESIN VITRO,” MIDDLE EAST JOURNAL OF CANCER, vol. 9, no. 1, pp. 35–40, 2018, [Online]. Available: https://sid.ir/paper/321195/en

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