Salivary Parameters as Predictive Markersfor Radiation-induced TreatmentResponse in Head and Neck Cancers: An Investigational Study

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Jayachander Dipika; SHIVASHANKARA ARNADI RAMACHANDRAYYA; Vidyasagar Mamidipudi Srinivasa; Tonse Raees; Pais Sarita; Lobo Ashwin DL; HEGDE SANATH KUMAR; RAO SURESH; BALIGA MANJESHWAR SHRINATH

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Journal: MIDDLE EAST JOURNAL OF CANCER Year:2018 | Volume:9 | Issue:2 Page(s): 133-142

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Title

Salivary Parameters as Predictive Markersfor Radiation-induced TreatmentResponse in Head and Neck Cancers: An Investigational Study

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Keywords

Salivary amylase

Glutathione

Lipid peroxides

Lactate dehydrogenase

Tumor response

Predictive assay

Abstract

Background: This study evaluates the predictive significance of Salivary amylase, Glutathione, Lipid peroxides, and Lactate dehydrogenase in the treatment of head andneck cancer patients who undergo curative radiotherapy/chemoradiotherapy. Methods: The volunteers for the study included head and neck cancer patients thatrequired curative radiotherapy/chemoradiotherapy. Patients provided saliva and bloodsamples before the start of radiation treatment and 24 hours after the first radiation fractionof 2 Gy (before the start of the second fraction). Samples were assessed for the levelsof blood and Salivary amylase, Glutathione, Lipid peroxides, and Lactate dehydrogenaseby standard laboratory methods. Clinical tumor radioresponse was assessed one monthafter the completion of treatment as complete responders, partial responders, andnonresponders. Results: The results indicated a significant increase in the levels of amylase, Lactate dehydrogenase, and Lipid peroxides; and a concomitant decrease in the levelsof Glutathione P<0. 05-P<0. 0001 in saliva and blood. The correlation between thedifferences in each biochemical parameter with that of the treatment response showeda significant correlation only for the salivary Lactate dehydrogenase (R2=0. 25; P<0. 02). Conclusion: The results indicate that salivary Lactate dehydrogenase can be auseful predictive marker to ascertain radiation-induced tumor regression in head andneck cancers.

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APA: Copy

Jayachander, Dipika, SHIVASHANKARA, ARNADI RAMACHANDRAYYA, Vidyasagar, Mamidipudi Srinivasa, Tonse, Raees, Pais, Sarita, Lobo, Ashwin DL, HEGDE, SANATH KUMAR, RAO, SURESH, & BALIGA, MANJESHWAR SHRINATH. (2018). Salivary Parameters as Predictive Markersfor Radiation-induced TreatmentResponse in Head and Neck Cancers: An Investigational Study. MIDDLE EAST JOURNAL OF CANCER, 9(2), 133-142. SID. https://sid.ir/paper/321227/en

Vancouver: Copy

Jayachander Dipika, SHIVASHANKARA ARNADI RAMACHANDRAYYA, Vidyasagar Mamidipudi Srinivasa, Tonse Raees, Pais Sarita, Lobo Ashwin DL, HEGDE SANATH KUMAR, RAO SURESH, BALIGA MANJESHWAR SHRINATH. Salivary Parameters as Predictive Markersfor Radiation-induced TreatmentResponse in Head and Neck Cancers: An Investigational Study. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2018;9(2):133-142. Available from: https://sid.ir/paper/321227/en

IEEE: Copy

Dipika Jayachander, ARNADI RAMACHANDRAYYA SHIVASHANKARA, Mamidipudi Srinivasa Vidyasagar, Raees Tonse, Sarita Pais, Ashwin DL Lobo, SANATH KUMAR HEGDE, SURESH RAO, and MANJESHWAR SHRINATH BALIGA, “Salivary Parameters as Predictive Markersfor Radiation-induced TreatmentResponse in Head and Neck Cancers: An Investigational Study,” MIDDLE EAST JOURNAL OF CANCER, vol. 9, no. 2, pp. 133–142, 2018, [Online]. Available: https://sid.ir/paper/321227/en

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