مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

229
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

104
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Correlation between Certain Klotho GenePolymorphisms and IGF-1 Levels ofColorectal Cancer Patients in Northern Iran

Pages

  151-157

Abstract

 Background: Colorectal cancer susceptibility may correlate with the Klothogene G-395A and C1818T polymorphisms. This study aims to evaluate the relationshipbetween a Klotho single nucleotide polymorphism and IGF-1 with risk of colorectalcancer. Methods: This study enrolled 60 Colorectal cancer patients and 60 age-matchedhealthy persons who referred to Razi Hospital, Rasht, and Northern Iran in September2013. Patients enrolled under supervision of a gastro-intestinal specialist andaccording to the ethics right. G-395A and C1818T polymorphisms were genotypedwith polymerase chain confronting two pair primer technology. IGF-1 and certainbiochemistry analytes were assayed. Statistical analysis was used to compareappropriate relationships. Results: There were different base pair partitions for G395A and C1818T. Oddsratio and 95% confidence interval were used to analyze the correlation of genotypesand haplotypes with Colorectal cancer susceptibility. The AA (odds ratio: 1. 437, 95%confidence interval: 0. 596) and GA (odds ratio: 1. 958, 95% confidence interval: 1. 133-3. 385) genotypes of the G-395A polymorphisms showed a slight relationship to therisk of Colorectal cancer. The A allele had a much higher frequency in the case group(31. 2%) compared with the control group (17. 6%). There was no significantrelationship with the C1818T polymorphism between the case and control groups. Conclusion: The Klotho gene polymorphism did not significantly increase therisk of Colorectal cancer. Therefore, these genotypes might not have a correlation withIGF-1.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    FATHI, MOJTABA, Goodarzvand, Omid, Aghjany Nasab, Monireh, MANSOUR GHANAEI, FARIBORZ, & Nazarian, Aboalfazl. (2018). Correlation between Certain Klotho GenePolymorphisms and IGF-1 Levels ofColorectal Cancer Patients in Northern Iran. MIDDLE EAST JOURNAL OF CANCER, 9(2), 151-157. SID. https://sid.ir/paper/321237/en

    Vancouver: Copy

    FATHI MOJTABA, Goodarzvand Omid, Aghjany Nasab Monireh, MANSOUR GHANAEI FARIBORZ, Nazarian Aboalfazl. Correlation between Certain Klotho GenePolymorphisms and IGF-1 Levels ofColorectal Cancer Patients in Northern Iran. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2018;9(2):151-157. Available from: https://sid.ir/paper/321237/en

    IEEE: Copy

    MOJTABA FATHI, Omid Goodarzvand, Monireh Aghjany Nasab, FARIBORZ MANSOUR GHANAEI, and Aboalfazl Nazarian, “Correlation between Certain Klotho GenePolymorphisms and IGF-1 Levels ofColorectal Cancer Patients in Northern Iran,” MIDDLE EAST JOURNAL OF CANCER, vol. 9, no. 2, pp. 151–157, 2018, [Online]. Available: https://sid.ir/paper/321237/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button