Prognostic Significance of MGMT PromoterMethylation in Patients with GlioblastomaUndergoing Surgical Intervention: ARetrospective Study in Northeastern Iran

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ANVARI KAZEM; SEILANIAN TOUSSI MEHDI; AYATOLLAHI HOSSEIN; BAHADORKHAN GHOLAMREZA; Ghavam Nasiri Mohammadreza; FAZL ERSI MITRA

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Journal: MIDDLE EAST JOURNAL OF CANCER Year:2018 | Volume:9 | Issue:3 Page(s): 179-185

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Title

Prognostic Significance of MGMT PromoterMethylation in Patients with GlioblastomaUndergoing Surgical Intervention: ARetrospective Study in Northeastern Iran

Author(s)

Keywords

Glioblastoma

MGMT gene

Promoter

Methylation

Abstract

Background: The standard of care for Glioblastoma is concurrent chemoradiotherapyand adjuvant chemotherapy with Temozolomide. In this trial, we have investigatedthe impact of MGMT Promoter Methylation on prognosis and benefit fromTemozolomide based chemotherapy in a group of patients with Glioblastoma in ourregion. Methods: This retrospective study included Glioblastoma patients treated in ourinstitute between 2006 and 2011. We used Methylation specific PCR to detectmethylation in the Promoter region of the MGMT gene. The Kaplan-Meier techniquewas used to calculate overall survival from the time of diagnosis to the time of death. We utilized the log-rank test and Cox-regression model for univariate and multivariateanalyses of potential prognostic factors. Results: There were 78 patient participants with a median age of 50 (range: 20 to75) years and a male to female ratio of 56/22. All patients underwent minimal surgicalresection which was considered as a biopsy. All patients received adjuvant radiotherapywith a median dose of 60 Gy (54-60 Gy) and 25 patients received concomitantTemozolomide. The MGMT Promoter Methylation was found in 19 (24. 4%) patientsand was relatively more frequent in men (28. 6%) compared to women (13. 6%; P=0. 16). This genetic change was associated with a significantly higher 2-year survivalin men (57. 2%) compared to women (16. 8%; P<0. 001). Multivariate analysis indicatedthat male sex and MGMT Promoter Methylation were independently associated withmore favorable prognosis. Conclusion: In our series, MGMT Promoter Methylation was a significantindependent prognostic factor. The finding of sex as an independent prognostic factorwould need further validation.

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APA: Copy

ANVARI, KAZEM, SEILANIAN TOUSSI, MEHDI, AYATOLLAHI, HOSSEIN, BAHADORKHAN, GHOLAMREZA, Ghavam Nasiri, Mohammadreza, & FAZL ERSI, MITRA. (2018). Prognostic Significance of MGMT PromoterMethylation in Patients with GlioblastomaUndergoing Surgical Intervention: ARetrospective Study in Northeastern Iran. MIDDLE EAST JOURNAL OF CANCER, 9(3), 179-185. SID. https://sid.ir/paper/321244/en

Vancouver: Copy

ANVARI KAZEM, SEILANIAN TOUSSI MEHDI, AYATOLLAHI HOSSEIN, BAHADORKHAN GHOLAMREZA, Ghavam Nasiri Mohammadreza, FAZL ERSI MITRA. Prognostic Significance of MGMT PromoterMethylation in Patients with GlioblastomaUndergoing Surgical Intervention: ARetrospective Study in Northeastern Iran. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2018;9(3):179-185. Available from: https://sid.ir/paper/321244/en

IEEE: Copy

KAZEM ANVARI, MEHDI SEILANIAN TOUSSI, HOSSEIN AYATOLLAHI, GHOLAMREZA BAHADORKHAN, Mohammadreza Ghavam Nasiri, and MITRA FAZL ERSI, “Prognostic Significance of MGMT PromoterMethylation in Patients with GlioblastomaUndergoing Surgical Intervention: ARetrospective Study in Northeastern Iran,” MIDDLE EAST JOURNAL OF CANCER, vol. 9, no. 3, pp. 179–185, 2018, [Online]. Available: https://sid.ir/paper/321244/en

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