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Information Journal Paper

Title

Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study

Pages

  103-110

Abstract

 Background: In this study, we sought to understand the usefulness of Salivary lactate dehydrogenase as a predictive marker for the development of radiation-induced Mucositis. Methods: This was a prospective study with Head and neck cancer patients who required curative radiotherapy (>60Gy). We collected patients’ saliva before the onset of radiation and after 2 Gy of radiation to assess lactate dehydrogenase levels. The patients received the stipulated oral and dental care. Data on incidence and severity of Mucositis was collected using a preform sheet and oral Mucositis assessment scale published by the Radiation Therapy Oncology Group throughout the 7-week treatment period. Results: Salivary lactate dehydrogenase increased with exposure to radiation (P<0. 0001) and there was an observed association with Mucositis severity (P<0. 0001; r = 0. 515). Conclusion: The present results have established, for the first time, that Salivary lactate dehydrogenase could be a useful predictive marker to understand the development of radiation-induced Mucositis in patients with Head and neck cancer. The proximity of the oral cavity for regular observation and saliva collection is an added advantage.

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    Cite

    APA: Copy

    Shivashankara, Arnadi R., Tonse, Raees, SURESH, SUCHARITHA, GEORGE, THOMAS, Vidyasagar, Mamidipudi Srinivasa, RAO, SURESH, & BALIGA, MANJESHWAR SHRINATH. (2019). Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study. MIDDLE EAST JOURNAL OF CANCER, 10(2), 103-110. SID. https://sid.ir/paper/321280/en

    Vancouver: Copy

    Shivashankara Arnadi R., Tonse Raees, SURESH SUCHARITHA, GEORGE THOMAS, Vidyasagar Mamidipudi Srinivasa, RAO SURESH, BALIGA MANJESHWAR SHRINATH. Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study. MIDDLE EAST JOURNAL OF CANCER[Internet]. 2019;10(2):103-110. Available from: https://sid.ir/paper/321280/en

    IEEE: Copy

    Arnadi R. Shivashankara, Raees Tonse, SUCHARITHA SURESH, THOMAS GEORGE, Mamidipudi Srinivasa Vidyasagar, SURESH RAO, and MANJESHWAR SHRINATH BALIGA, “Salivary Lactate Dehydrogenase (LDH) as a Marker for Radiation-induced Mucositis in Head and Neck Cancers: A Preliminary Study,” MIDDLE EAST JOURNAL OF CANCER, vol. 10, no. 2, pp. 103–110, 2019, [Online]. Available: https://sid.ir/paper/321280/en

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