EXEMESTANE LOADED POLYMERIC NANOPARTICLES FOR ORAL DELIVERY

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SRINIVAS PRATHIMA; SUMAPRIYA T.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Nano Dimension Year:2014 | Volume:5 | Issue:SPECIAL ISSUE 6 Page(s): 539-548

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Information Journal Paper

Title

EXEMESTANE LOADED POLYMERIC NANOPARTICLES FOR ORAL DELIVERY

Author(s)

SRINIVAS PRATHIMA | SUMAPRIYA T. | Issue Writer Certificate

Keywords

POLYMERIC NANOPARTICLES

EXEMESTANE

EUDRAGIT® RL 100

EUDRAGIT L 100

PLURONIC® F-68

Abstract

The aim of the present study was to develop EXEMESTANE loaded POLYMERIC NANOPARTICLES for improved oral bioavailability of EXEMESTANE. EXEMESTANE loaded nanoparticles were prepared by solvent displacement method with Eudragit RL 100 and EUDRAGIT L 100 as polymers and Pluronic Ò F-68 as surfactant. The influence of various formulation factors (drug: polymer ratio and concentration of surfactant) on particle size, size distribution, zeta potential, encapsulation efficiency, in vitro drug release were investigated. The mean particle size of optimized formulations F5 and F13 were found to be 98.19nm and 48.16nm respectively. Zeta potential of optimized formulations F5 and F13 were found to be+22mV and -25mV respectively. Fourier Transform Infrared Spectroscopy (FT-IR) study indicated that, there was no interaction between drug and polymers. Scanning electron microscopy (SEM) study revealed spherical morphology of the developed NPs. The results of the present investigation indicate that the formulations F5 and F13 can be considered as best among various formulations with respect to particle size, entrapment efficiency and in-vitro drug release. In conclusion, this study indicates the capability of Eudragit nanoparticles in enhancing the oral bioavailability of EXEMESTANE.

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APA: Copy

SRINIVAS, PRATHIMA, & SUMAPRIYA, T.. (2014). EXEMESTANE LOADED POLYMERIC NANOPARTICLES FOR ORAL DELIVERY. INTERNATIONAL JOURNAL OF NANO DIMENSION (IJND), 5(SPECIAL ISSUE 6), 539-548. SID. https://sid.ir/paper/322261/en

Vancouver: Copy

SRINIVAS PRATHIMA, SUMAPRIYA T.. EXEMESTANE LOADED POLYMERIC NANOPARTICLES FOR ORAL DELIVERY. INTERNATIONAL JOURNAL OF NANO DIMENSION (IJND)[Internet]. 2014;5(SPECIAL ISSUE 6):539-548. Available from: https://sid.ir/paper/322261/en

IEEE: Copy

PRATHIMA SRINIVAS, and T. SUMAPRIYA, “EXEMESTANE LOADED POLYMERIC NANOPARTICLES FOR ORAL DELIVERY,” INTERNATIONAL JOURNAL OF NANO DIMENSION (IJND), vol. 5, no. SPECIAL ISSUE 6, pp. 539–548, 2014, [Online]. Available: https://sid.ir/paper/322261/en

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