مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SYNTHESIS AND OPTIMIZATION OF CHITOSAN NANOPARTICLES: POTENTIAL APPLICATIONS IN NANOMEDICINE AND BIOMEDICAL ENGINEERING

Pages

  156-161

Abstract

 Background: CHITOSAN NANOPARTICLEs have become of great interest for NANOMEDICINE, BIOMEDICAL ENGINEERING and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. The aim of the present study was to synthesis and optimize of the CHITOSAN NANOPARTICLEs for industrial and biomedical applications.Methods: Fe3O4 was synthesized and optimized as magnetic core NANOPARTICLEs and then CHITOSAN covered this magnetic core. The size and morphology of the nano-magnetic CHITOSAN was analyzed by scanning electron microscope (SEM). Topography and size distribution of the NANOPARTICLEs were shown with two-dimensional and three-dimensional images of atomic force microscopy (AFM). The NANOPARTICLEs were analyzed using transmission electron microscopy (TEM).Results: The CHITOSAN NANOPARTICLEs prepared in the experiment exhibited white powder shape. The SEM micrographs of the nano-magnetic CHITOSAN showed that they were approximately uniform spheres. The unmodified CHITOSAN NANOPARTICLEs composed of clusters of NANOPARTICLEs with sizes ranging from 10 nm to 80 nm. AFM provides a three-dimensional surface profile. The TEM image showed physical aggregation of the CHITOSAN NANOPARTICLEs.Conclusion: The results show that a novel CHITOSAN NANOPARTICLE was successfully synthesized and characterized. It seems that this NANOPARTICLE like the other CHITOSAN nano particles has potential applications for NANOMEDICINE, BIOMEDICAL ENGINEERING, industrial and pharmaceutical fields.

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    • Cite

    APA: Copy

    GHADI, AREZOU, MAHJOUB, SOLEIMAN, TABANDEH, FATEMEH, & TALEBNIA, FARID. (2014). SYNTHESIS AND OPTIMIZATION OF CHITOSAN NANOPARTICLES: POTENTIAL APPLICATIONS IN NANOMEDICINE AND BIOMEDICAL ENGINEERING. CASPIAN JOURNAL OF INTERNAL MEDICINE, 5(3), 156-161. SID. https://sid.ir/paper/323368/en

    Vancouver: Copy

    GHADI AREZOU, MAHJOUB SOLEIMAN, TABANDEH FATEMEH, TALEBNIA FARID. SYNTHESIS AND OPTIMIZATION OF CHITOSAN NANOPARTICLES: POTENTIAL APPLICATIONS IN NANOMEDICINE AND BIOMEDICAL ENGINEERING. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2014;5(3):156-161. Available from: https://sid.ir/paper/323368/en

    IEEE: Copy

    AREZOU GHADI, SOLEIMAN MAHJOUB, FATEMEH TABANDEH, and FARID TALEBNIA, “SYNTHESIS AND OPTIMIZATION OF CHITOSAN NANOPARTICLES: POTENTIAL APPLICATIONS IN NANOMEDICINE AND BIOMEDICAL ENGINEERING,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 5, no. 3, pp. 156–161, 2014, [Online]. Available: https://sid.ir/paper/323368/en

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