مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

Effect of a 12-week sub-maximal swimming training in rats exposed to tobacco-derived nitrosamine ketone

Pages

  158-163

Abstract

 Background: Tobacco contains carcinogens such as NNK (nicotine-derived nitrosamine ketone) that makes induction of lung cancer by changing the stimulation of IL-10 expression. The aim of this study was to investigate changes in resting levels of IL-10 in lung tissues of rats exposed to NNK after a 12-week aerobic submaximal swimming training. Methods: For this purpose, 46 Wistar rats were randomly divided into five groups consisting training, training + NNK, NNK, saline and control. NNK-induced groups received NNK subcutaneously one day per week at a rate of 12/5 mg per kg body weight and the training groups performed submaximal swimming training for 12 weeks. The levels of IL-10 in homogenized lung tissue were measured by ELISA. Results: Findings indicated that a period of swimming training increased the IL-10 levels significantly in lung tissue of training group when compared to control (P=0. 00) and NNK groups (P=0. 00). Also, a significant increase of IL-10 level was observed in exercise + NNK group when compared to NNK group (p≤ 0/02). Furthermore, it was observed that IL-10 levels of NNK group had a significant decrease when compared to training group (P=0/00), training + NNK group (p≤ 0/02), but had insignificant increase when compared to saline group (p≤ 0/85). Conclusions: Generally, it could be confirmed that regular submaximal aerobic training plays an important role in the inhibition of the effects of lung Inflammation induced by NNK via increasing IL-10 activity.

Cites

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    • Cite

    APA: Copy

    BARZEGARI, ALI, & MIRDAR, SHADMEHR. (2018). Effect of a 12-week sub-maximal swimming training in rats exposed to tobacco-derived nitrosamine ketone. CASPIAN JOURNAL OF INTERNAL MEDICINE, 9(2), 158-163. SID. https://sid.ir/paper/323516/en

    Vancouver: Copy

    BARZEGARI ALI, MIRDAR SHADMEHR. Effect of a 12-week sub-maximal swimming training in rats exposed to tobacco-derived nitrosamine ketone. CASPIAN JOURNAL OF INTERNAL MEDICINE[Internet]. 2018;9(2):158-163. Available from: https://sid.ir/paper/323516/en

    IEEE: Copy

    ALI BARZEGARI, and SHADMEHR MIRDAR, “Effect of a 12-week sub-maximal swimming training in rats exposed to tobacco-derived nitrosamine ketone,” CASPIAN JOURNAL OF INTERNAL MEDICINE, vol. 9, no. 2, pp. 158–163, 2018, [Online]. Available: https://sid.ir/paper/323516/en

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