L-CARNITINE SUPPLEMENTATION IN UREMIC PATIENTS (LETTER TO EDITOR)

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ROSTAMI ZOHREH; NEMATI EGHLIM

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Journal Paper

Paper Information

Journal: Nephro-Urology Monthly Year:2011 | Volume:3 | Issue:3 (9) Page(s): 209-210

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Information Journal Paper

Title

L-CARNITINE SUPPLEMENTATION IN UREMIC PATIENTS (LETTER TO EDITOR)

Author(s)

ROSTAMI ZOHREH | NEMATI EGHLIM | Issue Writer Certificate

Keywords

L-CARNITINE

ANEMIA

HEMODIALYSIS

Abstract

We read with interest the paper of Debska-Slizien Aet al.(1), recently published in Nephro-Urology Monthly which focused on the impact of L-CARNITINE on management of ANEMIA among dialysis patients. We know that plasma free carnitine concentration in HEMODIALYSIS patients is reduced (19.2-32.4 umol/L) and significantly lower than in healthy controls (40-50 umol/L) or in chronic kidney disease patients. Several factors contribute to this abnormal profile (2) containing of reduction in endogenous carnitine synthesis and limitation in dietary intake and HEMODIALYSIS removal. We are agree with Debska-Slizien Aet al. that L-CARNITINE may increase blood hemoglobin levels in HEMODIALYSIS patients without erythropoietin therapy, and may decrease erythropoietin dose in HEMODIALYSIS patients who receives combined therapy with L-CARNITINE and erythropoietin (3). Furthermore, L-CARNITINE supplementation may improve several situations, such as cardiac performance, intradialytic hypotension, muscle symptoms, and impaired exercise and functional capacities in HEMODIALYSIS patients. On the other hand, it could have a positive impact on nutritional status of uremic patients by positive protein balance induction, insulin resistance reduction, and chronic inflammation amelioration (4). So it seems that L-CARNITINE administration might be rational in HEMODIALYSIS patients. However, there is still a big controversy surrounding L-CARNITINE supplementation in dialysis patients (5), and limited data is also available on possible benefits of L-CARNITINE supplementation in uremic patients (3).

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APA: Copy

ROSTAMI, ZOHREH, & NEMATI, EGHLIM. (2011). L-CARNITINE SUPPLEMENTATION IN UREMIC PATIENTS (LETTER TO EDITOR). THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, 3(3 (9)), 209-210. SID. https://sid.ir/paper/323684/en

Vancouver: Copy

ROSTAMI ZOHREH, NEMATI EGHLIM. L-CARNITINE SUPPLEMENTATION IN UREMIC PATIENTS (LETTER TO EDITOR). THE JOURNAL OF NEPHRO-UROLOGY MONTHLY[Internet]. 2011;3(3 (9)):209-210. Available from: https://sid.ir/paper/323684/en

IEEE: Copy

ZOHREH ROSTAMI, and EGHLIM NEMATI, “L-CARNITINE SUPPLEMENTATION IN UREMIC PATIENTS (LETTER TO EDITOR),” THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, vol. 3, no. 3 (9), pp. 209–210, 2011, [Online]. Available: https://sid.ir/paper/323684/en

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