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Information Journal Paper

Title

VASCULAR INVOLVEMENT IN PRIMARY HYPEROXALOSIS: AN EVIDENCE BASED SYTEMATIC OVERVIEW OVER A FIFTY YEAR SPAN

Pages

  390-396

Abstract

 Background and Aims: Primary hyperoxaluria (PH) is a rare genetic disorder characterized by calcium oxalate NEPHROCALCINOSIS leading to renal failure. When renal function is impaired, plasma oxalate concentration increases and extra-renal oxalate deposition occurs. Vascular involvement includes VASCULITIS and ischemic related morbidity and death. The prevalence of vascular involvement is not known with only a few cases described in the literature. A systematic overview of the literature was performed to identify the demographics, clinical presentation and outcomes of such patients.Methods: A computerized search of MEDLINE (Jan 1950 to May 30, 2007), EMBASE (Jan 1988 to May 2007) and CINAHL (Jan 1982 to May 30, 2007 identified twenty three cases of vascular involvement.Results: The majority of those reported in the literature are young females (74%). Vascular deposition of oxalate crystals presents as skin VASCULITIS, limb or mesenteric ischemia or GANGRENE. Stroke is uncommon.The lower limbs are affected more than upper limbs followed by mesenteric vessels. Vasculitic skin manifestations occur in 52% of cases. Death occurred in 8 (38%) of cases (63% abdominal GANGRENE/sepsis, 37% cardiac).Conclusions: Little information exists on vascular involvement in PH. Morbidity and mortality is high (death and limb loss occurring in 2.3 of patients). Awareness of the vascular presentation is thus important to allow a better understanding. Prospective reporting via a national or international registry on optimal management of vascular involvement in PH is needed.

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    APA: Copy

    MOOKADAM, FAROUK, KHEIR, MOHAMMED EL, ALHARTHI, MOHSEN, MOUSTAFA, SHERIF, KAZMIER, FRANCI J., MCBAIN, ROBERT, MOOKADAM, MARTINA, TAJIK, JAMIL, & MILLINER, DAWN S.. (2010). VASCULAR INVOLVEMENT IN PRIMARY HYPEROXALOSIS: AN EVIDENCE BASED SYTEMATIC OVERVIEW OVER A FIFTY YEAR SPAN. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, 2(3), 390-396. SID. https://sid.ir/paper/323713/en

    Vancouver: Copy

    MOOKADAM FAROUK, KHEIR MOHAMMED EL, ALHARTHI MOHSEN, MOUSTAFA SHERIF, KAZMIER FRANCI J., MCBAIN ROBERT, MOOKADAM MARTINA, TAJIK JAMIL, MILLINER DAWN S.. VASCULAR INVOLVEMENT IN PRIMARY HYPEROXALOSIS: AN EVIDENCE BASED SYTEMATIC OVERVIEW OVER A FIFTY YEAR SPAN. THE JOURNAL OF NEPHRO-UROLOGY MONTHLY[Internet]. 2010;2(3):390-396. Available from: https://sid.ir/paper/323713/en

    IEEE: Copy

    FAROUK MOOKADAM, MOHAMMED EL KHEIR, MOHSEN ALHARTHI, SHERIF MOUSTAFA, FRANCI J. KAZMIER, ROBERT MCBAIN, MARTINA MOOKADAM, JAMIL TAJIK, and DAWN S. MILLINER, “VASCULAR INVOLVEMENT IN PRIMARY HYPEROXALOSIS: AN EVIDENCE BASED SYTEMATIC OVERVIEW OVER A FIFTY YEAR SPAN,” THE JOURNAL OF NEPHRO-UROLOGY MONTHLY, vol. 2, no. 3, pp. 390–396, 2010, [Online]. Available: https://sid.ir/paper/323713/en

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