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Information Journal Paper

Title

SF36 QUALITY OF LIFE AND MORTALITY ACROSS DIFFERENT LEVELS OF SERUM ALBUMIN IN PATIENTS WITH HEMODIALYSIS

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Abstract

 Background: Patients on HEMODIALYSIS (HD) generally display a significant decrease in the quality of life owing to comorbidities, malnutrition, and INFLAMMATION.Methods: In this multicenter prospective study, the SF36 (short form with 36 questions scored between 0 and 100) and relevant demographic data and comorbidities (charlson comorbidity index); NUTRITIONal factors, and C-reactive protein (CRP) were evaluated in 416 HD patients in September 2012. Hospitalization and mortality were assessed in a median of a 28 month follow-up.Results: The SF36 score in survived patients was 53.619.3 versus 41.622.4 in the non-survived patients (P<0.001). There were significant adjusted inverse correlation between the SF36 score and age (r=-0.14, P=0.005), diabetes (r=-0.13, P=0.009), CCI (r =-0.24, P<0.001), serum CRP level (r=-0.13, P=0.03), serum iPTH level (r=-0.19, P<0.001), and also significant adjusted direct correlation with serum albumin (r=0.15, P=0.003), and serum creatinine (r=0.12, P=0.04). In Cox proportional hazard models adjusting for age, gender, dialysis vintage, diabetes and serum albumin, the hazard ratio of death for every 10 unit decrease in SF36 score was 1.10 (95% CI: 1.04 - 1.22; P=0.006). The adjusted hazard ratio for quintiles of serum albumin as3.60, >3.60 - 3.85, >3.85 -4.00, >4.00 - 4.20, >4.20 (reference) g/dL was respectively 3.69 (1.98 - 6.89), 2.08 (1.10 - 3.94), 1.91 (0.97 - 3.85), 1.10 (0.76 - 1.49). Serum albumin revealed a strong association with mortality such that hazard ratio for every 1 g/dL decrease in serum albumin was 6.28 (95% CI: 3.80 - 10.42; P<0.001).Conclusions: In patients with HEMODIALYSIS, SF36 shows significant association with serum albumin, comorbidities, INFLAMMATION, and clinical outcome.

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    APA: Copy

    SOLEYMANIAN, TAYEBEH, NEJATI, MARAL, KABIRI ESFAHANI, MOHSEN, & ARGANI, HASSAN. (). . , (), -. SID. https://sid.ir/paper/323812/en

    Vancouver: Copy

    SOLEYMANIAN TAYEBEH, NEJATI MARAL, KABIRI ESFAHANI MOHSEN, ARGANI HASSAN. . [Internet]. ;():-. Available from: https://sid.ir/paper/323812/en

    IEEE: Copy

    TAYEBEH SOLEYMANIAN, MARAL NEJATI, MOHSEN KABIRI ESFAHANI, and HASSAN ARGANI, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/323812/en

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