INADVERTENT TREATMENT WITH A PURE IKR BLOCKER IN LQT2 SYNDROME

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HOSSEINKHANI MOHSEN; SABOOR FAHIMEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF CARDIAC SURGERY Year:2010 | Volume:3 | Issue:5 Page(s): 6-9

Download Full-Text

View:

308

Download:

101

Cites:

Information Journal Paper

Title

INADVERTENT TREATMENT WITH A PURE IKR BLOCKER IN LQT2 SYNDROME

Author(s)

HOSSEINKHANI MOHSEN | SABOOR FAHIMEH | Issue Writer Certificate

Keywords

LONG QT SYNDROME

TORSADES DE POINTS

NIFEKALANT

GENOTYPE

MISSENSE MUTATION

Abstract

LONG QT SYNDROME (LQTS) results from structural abnormalities in the potassium channels of the heart, which predispose affected persons to an accelerated heart rhythm (arrhythmia). NIFEKALANT, a new class III antiarrhythmic agent developed in US, blocks selectively a rapidly-activating component of the delayed rectifier potassium channel (IKr) in cardiac myocytes, and causes dose-dependent increase in artrial and ventricular refractory periods and repolarization. We report a case of congenital LONG QT SYNDROME (LQTS) with recurrent ventricular fibrillation inadvertently treated with intravenous NIFEKALANT. Treatment neither modified the rate-corrected QT interval nor induced TORSADES DE POINTS. Subsequent genotyping of the patient revealed a MISSENSE MUTATION in the extracellular loop between S5 and the pore region of HERG (K595E). Since HERG encodes the IKr channel, LQT2 patient may be more tolerant of pure IKr blockers than other LQTS GENOTYPEs.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

HOSSEINKHANI, MOHSEN, & SABOOR, FAHIMEH. (2010). INADVERTENT TREATMENT WITH A PURE IKR BLOCKER IN LQT2 SYNDROME. IRANIAN JOURNAL OF CARDIAC SURGERY, 3(5), 6-9. SID. https://sid.ir/paper/324152/en

Vancouver: Copy

HOSSEINKHANI MOHSEN, SABOOR FAHIMEH. INADVERTENT TREATMENT WITH A PURE IKR BLOCKER IN LQT2 SYNDROME. IRANIAN JOURNAL OF CARDIAC SURGERY[Internet]. 2010;3(5):6-9. Available from: https://sid.ir/paper/324152/en

IEEE: Copy

MOHSEN HOSSEINKHANI, and FAHIMEH SABOOR, “INADVERTENT TREATMENT WITH A PURE IKR BLOCKER IN LQT2 SYNDROME,” IRANIAN JOURNAL OF CARDIAC SURGERY, vol. 3, no. 5, pp. 6–9, 2010, [Online]. Available: https://sid.ir/paper/324152/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops