MAGNESIUM SUPPLEMENTATION DURING CARDIOPULMONARY BYPASS TO PREVENT JUNCTIONAL ECTOPIC TACHYCARDIA AFTER PEDIATRIC CARDIAC SURGERY: A RANDOMIZED CONTROLLED STUDY

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BAGHAEI R.

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Journal Paper

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Journal: IRANIAN JOURNAL OF CARDIAC SURGERY Year:2010 | Volume:3 | Issue:5 Page(s): 14-14

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Title

MAGNESIUM SUPPLEMENTATION DURING CARDIOPULMONARY BYPASS TO PREVENT JUNCTIONAL ECTOPIC TACHYCARDIA AFTER PEDIATRIC CARDIAC SURGERY: A RANDOMIZED CONTROLLED STUDY

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BAGHAEI R.

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Abstract

Objectives: We analyzed the role of magnesium sulfate (MgSO4) supplementation during cardiopulmonary bypass in pediatric patients undergoing cardiac surgery, assessing the incidence of hypomagnesemia and the incidence of junctional ectopic tachycardia.Methods: We performed a randomized, double-blind, controlled trial in 99 children. MgSO4 or placebo was administered during the rewarming phase of cardiopulmonary bypass: group 1, placebo group (29 patients); group 2, 25 mg/kg of MgSO4 (30 patients); and group 3, 50 mg/kg of MgSO4 (40 patients).Results: At the time of admission to the cardiac intensive care unit, groups receiving MgSO4 had significantly greater levels of ionized magnesium (group 1, 0.51±0.07; group 2, 0.57±0.09; group 3, 0.59±0.09). Hypomagnesemia before bypass was common (75%–86.2%) and not significantly different among the groups. The proportion of hypomagnesemia decreased significantly at admission to the cardiac intensive care unit in groups receiving MgSO4 (group 1, 77.8%; group 2, 63%; group 3, 47.4%). Patients receiving placebo (group 1) had a significantly greater occurrence of junctional ectopic tachycardia than groups receiving MgSO4 (group 1, n=5 [17.9%]; group 2, n=2 [6.7%]; group 3, n=0 [0%]). Age (<1 month), Aristotle score (>4), and history of cardiac failure were associated with junctional ectopic tachycardia. None of the patients with those characteristics in group 3 had junctional ectopic tachycardia. No association was found between study groups and the Pediatric Risk of Mortality score or length of stay in the cardiac intensive care unit.Conclusions: Supplementation with MgSO4 during cardiopulmonary bypass seems to reduce the incidence of hypomagnesemia and junctional ectopic tachycardia at admission to the cardiac intensive care unit. This effect seems to be dose related.

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APA: Copy

BAGHAEI, R.. (2010). MAGNESIUM SUPPLEMENTATION DURING CARDIOPULMONARY BYPASS TO PREVENT JUNCTIONAL ECTOPIC TACHYCARDIA AFTER PEDIATRIC CARDIAC SURGERY: A RANDOMIZED CONTROLLED STUDY. IRANIAN JOURNAL OF CARDIAC SURGERY, 3(5), 14-14. SID. https://sid.ir/paper/324153/en

Vancouver: Copy

BAGHAEI R.. MAGNESIUM SUPPLEMENTATION DURING CARDIOPULMONARY BYPASS TO PREVENT JUNCTIONAL ECTOPIC TACHYCARDIA AFTER PEDIATRIC CARDIAC SURGERY: A RANDOMIZED CONTROLLED STUDY. IRANIAN JOURNAL OF CARDIAC SURGERY[Internet]. 2010;3(5):14-14. Available from: https://sid.ir/paper/324153/en

IEEE: Copy

R. BAGHAEI, “MAGNESIUM SUPPLEMENTATION DURING CARDIOPULMONARY BYPASS TO PREVENT JUNCTIONAL ECTOPIC TACHYCARDIA AFTER PEDIATRIC CARDIAC SURGERY: A RANDOMIZED CONTROLLED STUDY,” IRANIAN JOURNAL OF CARDIAC SURGERY, vol. 3, no. 5, pp. 14–14, 2010, [Online]. Available: https://sid.ir/paper/324153/en

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