EFFECT OF ACUTE TOXICITY OF CADMIUM IN MICE KIDNEY CELLS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MASOOMI KARIMI MASOOMEH; JAFARI SANI MOSLEM; ZAREE MAHMUDABADI ALI; JAFARI SANI ASMA; KHATIBI SEYED REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF TOXICOLOGY Year:2012 | Volume:6 | Issue:18 Page(s): 691-698

Download Full-Text

View:

427

Download:

231

Cites:

Information Journal Paper

Title

EFFECT OF ACUTE TOXICITY OF CADMIUM IN MICE KIDNEY CELLS

Author(s)

Keywords

CADMIUM

COMET ASSAY

DNA DAMAGE

KIDNEY

OXIDATIVE STRESS

Abstract

BackgroundCADMIUM is one of the most toxic heavy metals in our environment having a very strong ability to accumulate in body organs, especially in KIDNEY. The present study was done to determine the genotoxicity and cytotoxicity in KIDNEYs of rats exposed to CADMIUM.MethodsMale rats (n=30), kept in standard conditions were used in this study. The animals were randomly divided into 2 groups (control and treatment). The treatment group was intraperitoneally injected with Cd (300 mm/kg) at hours 0, 6, 12, 24, 48. Twenty four hours after the last injection, the rats were sacrificed and their KIDNEYs were obtained. Then OXIDATIVE STRESS markers, malondialdehide (MDA), glutathione (GSH), and superoxide dismutase (SOD), were assayed in homogenized KIDNEY for studying their cytotoxicity. For genotoxicity and DNA DAMAGE studies, COMET ASSAY was run on isolated KIDNEY cells. Data analysis was done by t-test and ANOVA using SPSS software version 15.ResultsMDA and GSH concentrations in normal and Cd exposed KIDNEY cells were 287.01±37.30nmol/g.pr and 15.61±3.89 mmol/g.pr and 609.24±87.87nmol/g.pr and 28.52±5.22 mmol/g.pr, respectively. In addition, SOD activity in normal and Cd exposed KIDNEY cells were 77.75±4.12 and 218.91±5.40 U/mg.pr, respectively. COMET ASSAY results (content comet length, tail length, and head diameter) showed DNA breakage in the treatment group that was stimulated by Cd which was not seen in the control group. ConclusionThe results demonstrated the genotoxicity effect of Cd on KIDNEY cells as well as the ability of Cd to producing cytotoxicity.

Cites

No record.

References

No record.

Cite

APA: Copy

MASOOMI KARIMI, MASOOMEH, JAFARI SANI, MOSLEM, ZAREE MAHMUDABADI, ALI, JAFARI SANI, ASMA, & KHATIBI, SEYED REZA. (2012). EFFECT OF ACUTE TOXICITY OF CADMIUM IN MICE KIDNEY CELLS. IRANIAN JOURNAL OF TOXICOLOGY, 6(18), 691-698. SID. https://sid.ir/paper/324296/en

Vancouver: Copy

MASOOMI KARIMI MASOOMEH, JAFARI SANI MOSLEM, ZAREE MAHMUDABADI ALI, JAFARI SANI ASMA, KHATIBI SEYED REZA. EFFECT OF ACUTE TOXICITY OF CADMIUM IN MICE KIDNEY CELLS. IRANIAN JOURNAL OF TOXICOLOGY[Internet]. 2012;6(18):691-698. Available from: https://sid.ir/paper/324296/en

IEEE: Copy

MASOOMEH MASOOMI KARIMI, MOSLEM JAFARI SANI, ALI ZAREE MAHMUDABADI, ASMA JAFARI SANI, and SEYED REZA KHATIBI, “EFFECT OF ACUTE TOXICITY OF CADMIUM IN MICE KIDNEY CELLS,” IRANIAN JOURNAL OF TOXICOLOGY, vol. 6, no. 18, pp. 691–698, 2012, [Online]. Available: https://sid.ir/paper/324296/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops