EFFECTS OF VITAMIN C ON PARAOXONASE1 ARYLESTERASE ACTIVITY IN RATS EXPOSED TO ARSENIC

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ZARGARI FELOR; TABAGHCHI SAEEDY HAMID

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Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF TOXICOLOGY Year:2017 | Volume:11 | Issue:3 Page(s): 47-50

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Title

EFFECTS OF VITAMIN C ON PARAOXONASE1 ARYLESTERASE ACTIVITY IN RATS EXPOSED TO ARSENIC

Author(s)

ZARGARI FELOR | TABAGHCHI SAEEDY HAMID | Issue Writer Certificate

Keywords

ARSENIC

PARAOXONASE 1

RAT

VITAMIN C

Abstract

Background: ARSENIC as an environmental toxicant is able to induced oxidative stress. The present study aimed to evaluate of VITAMIN C supplementation on the paraoxonase1 (PON1) arylesterase activity (responsible for hydrolysing lipid-peroxides) in RAT exposed to ARSENIC.Methods: The study was conducted in the Faculty of Veterinary Medicine, Tabriz Islamic Azad University, Tabriz, Iran in 20015. Thirty-two adult male RATs weighing 200-350 g were randomly divided into 4 groups: group I (Normal healthy RAT), group II [treated with sodium arsenite (100 ppm in drinking water)], group III [treated with VITAMIN C supplementation (200 mg/kg via gavage)] group IV (treated with sodium arsenite and VITAMIN C 100 ppm and 200 mg/kg respectively).Results: VITAMIN C supplementation increased paraoxonase1 (PON1) arylesterase activity (P<0.05) but had no significant effect on serum levels of HDL, triglyceride and cholesterol.Conclusion: PON1 arylesterase activity is independent of changes in HDL and lipid profile, and VITAMIN C with different mechanisms such as radical scavenging activity and reduction of oxidative stress leads to increased activity of paraoxonase.

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APA: Copy

ZARGARI, FELOR, & TABAGHCHI SAEEDY, HAMID. (2017). EFFECTS OF VITAMIN C ON PARAOXONASE1 ARYLESTERASE ACTIVITY IN RATS EXPOSED TO ARSENIC. IRANIAN JOURNAL OF TOXICOLOGY, 11(3), 47-50. SID. https://sid.ir/paper/324475/en

Vancouver: Copy

ZARGARI FELOR, TABAGHCHI SAEEDY HAMID. EFFECTS OF VITAMIN C ON PARAOXONASE1 ARYLESTERASE ACTIVITY IN RATS EXPOSED TO ARSENIC. IRANIAN JOURNAL OF TOXICOLOGY[Internet]. 2017;11(3):47-50. Available from: https://sid.ir/paper/324475/en

IEEE: Copy

FELOR ZARGARI, and HAMID TABAGHCHI SAEEDY, “EFFECTS OF VITAMIN C ON PARAOXONASE1 ARYLESTERASE ACTIVITY IN RATS EXPOSED TO ARSENIC,” IRANIAN JOURNAL OF TOXICOLOGY, vol. 11, no. 3, pp. 47–50, 2017, [Online]. Available: https://sid.ir/paper/324475/en

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