IL23 AS A NOVEL SERUM BASED BIOMARKER IN ULCERATIVE COLITIS- AN EDITORIAL (EDITORIAL)

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CHAKRABORTY SUBHANKAR

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Journal Paper

Paper Information

Journal: Gastroenterology and Hepatology From Bed to Bench Year:2012 | Volume:5 | Issue:1 Page(s): 1-2

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Information Journal Paper

Title

IL23 AS A NOVEL SERUM BASED BIOMARKER IN ULCERATIVE COLITIS- AN EDITORIAL (EDITORIAL)

Author(s)

CHAKRABORTY SUBHANKAR | Issue Writer Certificate

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Abstract

IL23 is a heterodimeric member of the IL-12 cytokine family composed of two subunits, IL12p40 and IL23p19. It is produced by antigen presenting cells and has been shown to promote the production and survival of a distinct lineage of T-cells called TH17 cells (1). Studies have revealed that naive T cells when stimulated by TGFb and IL-6 are differentiate into TH17 cells. However, this is inhibited by the presence of IFN-g and IL-4. Once committed to the TH17 lineage, the TH17 cells remain committed even in presence of cytokines that stimulate other T cell lineages. Once activated, TH17 cells release several cytokines (including IL-6, IL-17A, IL-17F, GM-CSF, TNF, CXCL1 and CCL7) that have been shown to be involved in immune mediated diseases including Inflammatory bowel disease (IBD), rheumatoid arthritis, psoriasis and multiple sclerosis (1).

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APA: Copy

CHAKRABORTY, SUBHANKAR. (2012). IL23 AS A NOVEL SERUM BASED BIOMARKER IN ULCERATIVE COLITIS- AN EDITORIAL (EDITORIAL). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 5(1), 1-2. SID. https://sid.ir/paper/324558/en

Vancouver: Copy

CHAKRABORTY SUBHANKAR. IL23 AS A NOVEL SERUM BASED BIOMARKER IN ULCERATIVE COLITIS- AN EDITORIAL (EDITORIAL). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2012;5(1):1-2. Available from: https://sid.ir/paper/324558/en

IEEE: Copy

SUBHANKAR CHAKRABORTY, “IL23 AS A NOVEL SERUM BASED BIOMARKER IN ULCERATIVE COLITIS- AN EDITORIAL (EDITORIAL),” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 5, no. 1, pp. 1–2, 2012, [Online]. Available: https://sid.ir/paper/324558/en

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