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Information Journal Paper

Title

PHENOTYPICAL CHARACTERIZATION OF THE PERIPHERAL BLOOD T CELLS IN PATIENTS WITH CELIAC DISEASE: DOES IT DIFFERENTIATE SUSPICIOUS CELIAC DISEASE CASES?

Pages

  132-139

Abstract

 Aim: The present study aimed to study the immunological changes seen in the intestinal epithelium of the celiac patients could also be detected in the peripheral BLOOD lymphocyte populations.Background: CELIAC DISEASE (CD) is a small bowel enteropathy caused by permanent wheat gluten intolerance. One of the earliest signs of CD is an increase in the numbers of the intestinal intraepithelial lymphocytes (iIEL).Patients and methods: In this case-control study, totally 13 untreated subjects with acceptable criteria for CD without any complication and 16 healthy subjects without any positive criteria for CD were selected. Peripheral BLOOD T cells were analyzed by two-color FLOW CYTOMETRY in both groups.Results: The mean age of patients was 33.6±3.4 years and two patients had Marsh IIIB, five patients had Marsh IIIA and six patients had Marsh II histology class. The mean percentages of the gdTCR+ T cells in the patients were significantly higher than the controls (p=0.015). However, the mean percentages of the abTCR+ T cells were significantly lower in the untreated patients than the controls (p=0.025). There were no significant difference between the mean percentages of lymphocytes expressing the CD3, CD4 and CD8 molecules in the patients and the controls.Conclusion: The change in the percentages of the peripheral BLOOD T cells expressing the gdTCR and abTCR in the celiac patients could be used in conjunction with the other serological markers to identify new CD cases.

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    APA: Copy

    NATAJ ARAB, HADI HOSSEIN, MASJEDI, MOHSEN, ALSAHEBFOSOUL, FERESHTEH, MOKHTARI, MOJGAN, JAMALI, NAHID, EMAMI, MOHAMMAD HASSAN, & SAFFAEI, ALI. (2015). PHENOTYPICAL CHARACTERIZATION OF THE PERIPHERAL BLOOD T CELLS IN PATIENTS WITH CELIAC DISEASE: DOES IT DIFFERENTIATE SUSPICIOUS CELIAC DISEASE CASES?. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 8(2), 132-139. SID. https://sid.ir/paper/324612/en

    Vancouver: Copy

    NATAJ ARAB HADI HOSSEIN, MASJEDI MOHSEN, ALSAHEBFOSOUL FERESHTEH, MOKHTARI MOJGAN, JAMALI NAHID, EMAMI MOHAMMAD HASSAN, SAFFAEI ALI. PHENOTYPICAL CHARACTERIZATION OF THE PERIPHERAL BLOOD T CELLS IN PATIENTS WITH CELIAC DISEASE: DOES IT DIFFERENTIATE SUSPICIOUS CELIAC DISEASE CASES?. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2015;8(2):132-139. Available from: https://sid.ir/paper/324612/en

    IEEE: Copy

    HADI HOSSEIN NATAJ ARAB, MOHSEN MASJEDI, FERESHTEH ALSAHEBFOSOUL, MOJGAN MOKHTARI, NAHID JAMALI, MOHAMMAD HASSAN EMAMI, and ALI SAFFAEI, “PHENOTYPICAL CHARACTERIZATION OF THE PERIPHERAL BLOOD T CELLS IN PATIENTS WITH CELIAC DISEASE: DOES IT DIFFERENTIATE SUSPICIOUS CELIAC DISEASE CASES?,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 8, no. 2, pp. 132–139, 2015, [Online]. Available: https://sid.ir/paper/324612/en

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