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Title

CLINICAL AND IMMUNOLOGICAL RELEVANCE OF ANTI-NEURONAL ANTIBODIES IN CELIAC DISEASE WITH NEUROLOGICAL MANIFESTATIONS

Pages

  146-152

Abstract

 Aim: To assess anti-neuronal antibodies (NA) prevalence and their correlation with neurological disorders and bowel habits in CELIAC DISEASE (CD) patients.Background: Neurological manifestations are estimated to occur in about 10% of CELIAC DISEASE patients and NA to central nervous system (CNS) and enteric nervous system (ENS) are found in a significant proportion of them. Little is known about the clinical and immunological features in CD patients with neurological manifestations.Patients and methods: NA to CNS and ENS were investigated in 106 CD patients and in 60 controls with autoimmune disorders by indirect immunofluorescence on rat / primate cerebellar cortex and intestinal (small and large bowel) sections.Results: IgG NA to CNS (titer 1:50 - 1:400) were positive in 23 celiacs (21%), being more frequently detected in those with neurological disorders that in those without neurological dysfunction (49% vs. 8%, P<0.0001). Of the 26 celiacs (24%) with IgG NA to ENS, 11 out of 12 with an antibody titer > 1:200 had severe constipation. Only one patient with cerebellar ataxia and intestinal sub-occlusion was positive for NA to CNS and ENS. NA to CNS and ENS were found in 7% and 5% of controls, respectively.Conclusion: In CD the positivity of NA to CNS can be regarded as a marker of neurological manifestations. High titer NA to ENS are associated with severe constipation. The demonstration of NA to CNS and ENS suggests an immune-mediated pathogenesis leading to central neural impairment as well as gut dysfunction (hence constipation), respectively.

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    APA: Copy

    CAIO, GIACOMO, GIORGIO, ROBERTO DE, VENTURI, ALESSANDRO, GIANCOLA, FIORELLA, LATORRE, ROCCO, BOSCHETTI, ELISA, SERRA, MAURO, RUGGERI, EUGENIO, & VOLTA, UMBERTO. (2015). CLINICAL AND IMMUNOLOGICAL RELEVANCE OF ANTI-NEURONAL ANTIBODIES IN CELIAC DISEASE WITH NEUROLOGICAL MANIFESTATIONS. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 8(2), 146-152. SID. https://sid.ir/paper/324619/en

    Vancouver: Copy

    CAIO GIACOMO, GIORGIO ROBERTO DE, VENTURI ALESSANDRO, GIANCOLA FIORELLA, LATORRE ROCCO, BOSCHETTI ELISA, SERRA MAURO, RUGGERI EUGENIO, VOLTA UMBERTO. CLINICAL AND IMMUNOLOGICAL RELEVANCE OF ANTI-NEURONAL ANTIBODIES IN CELIAC DISEASE WITH NEUROLOGICAL MANIFESTATIONS. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2015;8(2):146-152. Available from: https://sid.ir/paper/324619/en

    IEEE: Copy

    GIACOMO CAIO, ROBERTO DE GIORGIO, ALESSANDRO VENTURI, FIORELLA GIANCOLA, ROCCO LATORRE, ELISA BOSCHETTI, MAURO SERRA, EUGENIO RUGGERI, and UMBERTO VOLTA, “CLINICAL AND IMMUNOLOGICAL RELEVANCE OF ANTI-NEURONAL ANTIBODIES IN CELIAC DISEASE WITH NEUROLOGICAL MANIFESTATIONS,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 8, no. 2, pp. 146–152, 2015, [Online]. Available: https://sid.ir/paper/324619/en

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