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Information Journal Paper

Title

CLINICAL CHARACTERISTICS AND RESPONSE TO THERAPY OF AUTOIMMUNE HEPATITIS IN AN URBAN LATINO POPULATION (BRIEF REPORT)

Pages

  225-230

Abstract

 Aim:We hypothesized that AIH outcomes might be different in our patient population that consists of a large number of Latinos.Background: Literature has suggested that the presentation and outcome of AUTOIMMUNE HEPATITIS can be different among different ethnicity and communities.Patients and methods: We performed a retrospective chart review of Latino patients with AIH diagnosed between 2002-2012. Complete and partial remissions were defined as normalization of liver enzyme values, or achieving less than twice the upper limit normal (ULN), respectively.Results: A total of 28 patients were identified. 26 (93%) were female. 13 (46%) had an acute presentation, one with type 2 AIH and 3 with ANA seronegative disease. The average pathologic stage (Ishak score) was 3.44±1.67 (range: 0-6). Complete and partial remission was achieved in 20 (71%) and 5 (18%) patients respectively. Ten patients (38%) required maintenance prednisone either alone (2), or in combination with Azathioprine (6) or Mycophenolate Mofetil (2). Remission in the majority of patients, including 14 (50%) who were cirrhotic. Six of 14 (43%) cirrhotic patients were asymptomatic at the time of diagnosis.Conclusion: In an urban Latino population, cirrhosis was the initial presentation of AIH in a significant percentage of patients raising concerns regarding insufficient screening for AIH in this patient population. A large number of patients required continuous prednisone to avoid relapse.

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    APA: Copy

    ZAHIRUDDIN, AYESHA, FARAHMAND, ABTIN, GAGLIO, PAUL, & MASSOUMI, HATEF. (2016). CLINICAL CHARACTERISTICS AND RESPONSE TO THERAPY OF AUTOIMMUNE HEPATITIS IN AN URBAN LATINO POPULATION (BRIEF REPORT). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 9(3), 225-230. SID. https://sid.ir/paper/324667/en

    Vancouver: Copy

    ZAHIRUDDIN AYESHA, FARAHMAND ABTIN, GAGLIO PAUL, MASSOUMI HATEF. CLINICAL CHARACTERISTICS AND RESPONSE TO THERAPY OF AUTOIMMUNE HEPATITIS IN AN URBAN LATINO POPULATION (BRIEF REPORT). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2016;9(3):225-230. Available from: https://sid.ir/paper/324667/en

    IEEE: Copy

    AYESHA ZAHIRUDDIN, ABTIN FARAHMAND, PAUL GAGLIO, and HATEF MASSOUMI, “CLINICAL CHARACTERISTICS AND RESPONSE TO THERAPY OF AUTOIMMUNE HEPATITIS IN AN URBAN LATINO POPULATION (BRIEF REPORT),” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 9, no. 3, pp. 225–230, 2016, [Online]. Available: https://sid.ir/paper/324667/en

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