Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology

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ROSTAMI NEJAD MOHAMMAD; Rezaei Tavirani Sina; MANSOURI VAHID; Jahani Sherafat Somayeh; Moravvej Farshi Hamideh

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Journal: Gastroenterology and Hepatology From Bed to Bench Year:2019 | Volume:12 | Issue:1 Page(s): 60-66

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Title

Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology

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Keywords

Colon cancer

gene

biomarker

Abstract

Aim: gene expression profile analysis of Colon cancer grade II into grade III transition by using system biology. Background: Colon cancer is one of lethal cancer in men and women. Treatment in advanced Colon cancer is difficult and survival rate is low. Methods: gene expression profiles of children patients with non-preforated appendicitis in comparison with the samples with nonappendicitis abdominal pain are analysis via protein – protein interaction PPI and the critical compounds are introduced by STITCH. Results: Six critical genes including MAPK3, AKT1, SRC, TP53, GAPDH, and ALB were identified as a possible biomarker panel related to Colon cancer grade II to III transition. Among these critical genes roles of MAPK3, AKT1, SRC, TP53 are highlighted. Conclusion: It was concluded that target therapy to regulate SRC and TP53 may be the effective therapeutic way to treatment of Colon cancer and more researches in necessary to design drugs for these purposes.

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APA: Copy

ROSTAMI NEJAD, MOHAMMAD, Rezaei Tavirani, Sina, MANSOURI, VAHID, Jahani Sherafat, Somayeh, & Moravvej Farshi, Hamideh. (2019). Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 12(1), 60-66. SID. https://sid.ir/paper/324740/en

Vancouver: Copy

ROSTAMI NEJAD MOHAMMAD, Rezaei Tavirani Sina, MANSOURI VAHID, Jahani Sherafat Somayeh, Moravvej Farshi Hamideh. Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2019;12(1):60-66. Available from: https://sid.ir/paper/324740/en

IEEE: Copy

MOHAMMAD ROSTAMI NEJAD, Sina Rezaei Tavirani, VAHID MANSOURI, Somayeh Jahani Sherafat, and Hamideh Moravvej Farshi, “Gene expression profile analysis of colon cancer grade II into grade III transition by using system biology,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 12, no. 1, pp. 60–66, 2019, [Online]. Available: https://sid.ir/paper/324740/en

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