Genetic association between a single nucleotide polymorphism in Interleukin-16 (rs4072111) and susceptibility to chronic HCV infection in an Iranian population

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KARKHANE MARYAM; MOHEBBI SEYED REZA; AZIMZADEH PEDRAM; Avarandeh Hasti; KAZEMIAN SHABNAM; SHARIFIAN AFSANEH; HATAMI BEHZAD; ASADZADEH AGHDAEI HAMID

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Journal: Gastroenterology and Hepatology From Bed to Bench Year:2018 | Volume:11 | Issue:1 Page(s): 42-47

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Genetic association between a single nucleotide polymorphism in Interleukin-16 (rs4072111) and susceptibility to chronic HCV infection in an Iranian population

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Abstract

Aim: Our goal was to identify the putative association of rs4072111 variant in IL-16 gene and HCV susceptibility in an Iranian population. Background: Interleukin 16 (IL-16), a multifunctional cytokine, plays a vital role in modulation of immune system. Methods: In present case control and cross sectional study, IL-16 gene variant in 300 patients with hepatitis C (HCV) infection and 300 healthy individuals were analyzed. To evaluate this possible association, genomic DNA from venous blood was extracted and genotypes of IL-16 rs4072111 variant were determined by polymerase chain reaction-Fragments Length Polymorphism Technique (PCR-RFLP). Then, rs4072111 C/T genotypes frequency and allelic distribution were evaluated in each group. Results: The results of genotyping showed 82% CC, 17. 3% CT, 0. 7% TT in the control group and 78% CC, 20% CT and 2% TT in the case group. The distribution of rs4072111 C allele was 90. 7% in controls and 88% in case group respectively. However, no correlation between IL-16 rs4072111 C/T variants and susceptibility to chronic HCV infection was found in the present study. Conclusion: We concluded the rs4072111 C/T cannot be considered as a proper biomarker to identify susceptibility to chronic hepatitis C virus infection.

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APA: Copy

KARKHANE, MARYAM, MOHEBBI, SEYED REZA, AZIMZADEH, PEDRAM, Avarandeh, Hasti, KAZEMIAN, SHABNAM, SHARIFIAN, AFSANEH, HATAMI, BEHZAD, & ASADZADEH AGHDAEI, HAMID. (2018). Genetic association between a single nucleotide polymorphism in Interleukin-16 (rs4072111) and susceptibility to chronic HCV infection in an Iranian population. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 11(1), 42-47. SID. https://sid.ir/paper/324757/en

Vancouver: Copy

KARKHANE MARYAM, MOHEBBI SEYED REZA, AZIMZADEH PEDRAM, Avarandeh Hasti, KAZEMIAN SHABNAM, SHARIFIAN AFSANEH, HATAMI BEHZAD, ASADZADEH AGHDAEI HAMID. Genetic association between a single nucleotide polymorphism in Interleukin-16 (rs4072111) and susceptibility to chronic HCV infection in an Iranian population. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2018;11(1):42-47. Available from: https://sid.ir/paper/324757/en

IEEE: Copy

MARYAM KARKHANE, SEYED REZA MOHEBBI, PEDRAM AZIMZADEH, Hasti Avarandeh, SHABNAM KAZEMIAN, AFSANEH SHARIFIAN, BEHZAD HATAMI, and HAMID ASADZADEH AGHDAEI, “Genetic association between a single nucleotide polymorphism in Interleukin-16 (rs4072111) and susceptibility to chronic HCV infection in an Iranian population,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 11, no. 1, pp. 42–47, 2018, [Online]. Available: https://sid.ir/paper/324757/en

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