Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer (brief report)

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Dokhaee Fatemeh; Mazhari Sogol; Galehdari Mohammad; BAHADORI MONFARED AYAD; BAGHAEI KAVEH

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Paper Information

Journal: Gastroenterology and Hepatology From Bed to Bench Year:2018 | Volume:11 | Issue:suppl 1 Page(s): 140-145

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Information Journal Paper

Title

Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer (brief report)

Author(s)

Keywords

Gastric cancer

Gastrokine-1(GKN1)

Gastrokine-2 (GKN2)

Real-time PCR

Abstract

Aim: The aim of this study was to investigate the expression of GKN1 and GKN2 genes as probable biomarkers for Gastric cancer. Background: Gastric cancer is a multifactorial process characterized by the uncontrolled growth and dissemination of abnormal cells. Survival rates of Gastric cancer tend to be poor, a plausible explanation is a combination of a late-stage diagnosis and limited access to treatment. In this regard, finding relevant and measurable biomarkers is urgently needed. Methods: 27 samples of Gastric cancer tissues were enrolled into this study, according to their pathological responses. The alteration of genes expression were evaluated by Real-time PCR technique. Results: Our findings showed the significant reduction of Gastrokin-1 and Gastrokine-2 genes expression in the cancerous specimens in comparison with the normal tissues. (P = 0. 008 and P = 0. 004 respectively). Conclusion: Our findings showed the significant reduction of Gastrokin-1 and Gastrokine-2 genes expression in the cancerous specimens in comparison with the normal tissues. (P = 0. 008 and P = 0. 004 respectively).

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APA: Copy

Dokhaee, Fatemeh, Mazhari, Sogol, Galehdari, Mohammad, BAHADORI MONFARED, AYAD, & BAGHAEI, KAVEH. (2018). Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer (brief report). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 11(suppl 1), 140-145. SID. https://sid.ir/paper/324819/en

Vancouver: Copy

Dokhaee Fatemeh, Mazhari Sogol, Galehdari Mohammad, BAHADORI MONFARED AYAD, BAGHAEI KAVEH. Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer (brief report). GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2018;11(suppl 1):140-145. Available from: https://sid.ir/paper/324819/en

IEEE: Copy

Fatemeh Dokhaee, Sogol Mazhari, Mohammad Galehdari, AYAD BAHADORI MONFARED, and KAVEH BAGHAEI, “Evaluation of GKN1 and GKN2 gene expression as a biomarker of gastric cancer (brief report),” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 11, no. suppl 1, pp. 140–145, 2018, [Online]. Available: https://sid.ir/paper/324819/en

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