مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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1

Information Journal Paper

Title

SRC and TP53 play critical role in low-grade dysplasia colorectal mucosa transformation into cancer

Pages

  105-110

Abstract

 Aim: Determination of crucial genes that are involved in onset and progress of dysplasia of colorectal mucosa is the aim of this study. Background: Management of dysplasia as one of the risk factors of colon cancer is very challenging. Molecular studies could be helpful in this matter. Here, the transcriptome profile of low-grade dysplasia in colon tissue in comparison with normal one is studied by protein-protein interaction (PPI) network analysis. Methods: For detecting differentially expressed genes (DEGs) of Dysplasia lesion, the data was downloaded from the gene chip GSE31106, platform GPL1261, GSM770092-94 as normal colorectal mucosa group and GSM770098-100 as low-grade dysplasia colorectal mucosa from the Gene Expression Omnibus database (GEO). The expression profile is evaluated by GEO2R and a network of DEGs is constructed and analyzed by Cytoscape algorithms. Results: The findings indicate that a PPI network analysis of 113 DEGs is consist of 8 nodes that 6 of them are common with inflammation state. Only SRC and TP53 were recognized as the specific makers for dysplasia. In this respect, a subnetwork of these two genes introduce a panel of 8 nodes consist of HRAS, MYC, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SRC, and TP53. Conclusion: It can be concluded that SRC and TP53 may play prominent role in dysplasia pathogenicity after running validation tests.

Cites

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    APA: Copy

    ASADZADEH AGHDAEI, HAMID, ZAMANIAN AZODI, MONA, VAFAEE, REZA, Moravvej Farshi, Hamideh, & NADERI, NOSRATOLLAH. (2018). SRC and TP53 play critical role in low-grade dysplasia colorectal mucosa transformation into cancer. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 11(suppl 1), 105-110. SID. https://sid.ir/paper/324822/en

    Vancouver: Copy

    ASADZADEH AGHDAEI HAMID, ZAMANIAN AZODI MONA, VAFAEE REZA, Moravvej Farshi Hamideh, NADERI NOSRATOLLAH. SRC and TP53 play critical role in low-grade dysplasia colorectal mucosa transformation into cancer. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2018;11(suppl 1):105-110. Available from: https://sid.ir/paper/324822/en

    IEEE: Copy

    HAMID ASADZADEH AGHDAEI, MONA ZAMANIAN AZODI, REZA VAFAEE, Hamideh Moravvej Farshi, and NOSRATOLLAH NADERI, “SRC and TP53 play critical role in low-grade dysplasia colorectal mucosa transformation into cancer,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 11, no. suppl 1, pp. 105–110, 2018, [Online]. Available: https://sid.ir/paper/324822/en

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