مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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1

Information Journal Paper

Title

Effects of butyric acid and arsenic on isolated pancreatic islets and liver mitochondria of male mouse

Pages

  44-53

Abstract

 Aim: The aim of the present study was to evaluate the different doses of Butyric acid (BA) and Arsenic (As) in Liver mitochondria oxidative stress and pancreatic Islet insulin secretion of male Mouse. Background: BA is found in many foods and As as a toxic metal is present in drinking water. They can induce oxidative stress in tissues. Materials and Methods: In this experimental study, Liver mitochondria were isolated by administration of the different centrifugation method and pancreatic Islets were isolated by collagenase method. Mitochondria were incubated by BA (35, 75, 150, 300 μ M) and As (20, 50, 100, 200 μ M) as the Islets were incubated by BA (250, 500, 1000, 1500 μ M) and As (50, 100, 200 μ M) for 1 hour. At the end of the experiment, mitochondrial viability and membrane potential, ROS, MDA, GSH and Islets insulin secretion were measured by their specific methods. Results: BA and As administration increased mitochondrial levels of ROS, MDA and decreased GSH and pancreatic Islet insulin secretion in a dose dependent manner (p<0. 05). The doses of BA 75μ M and As 100μ M have been revealed the most mitochondria toxic concentrations. Also, the doses of 1000μ M for BA and 100μ M for As were considered as reducing concentrations for Islets insulin secretion. Additionally, co administration of them intensified more these effects Conclusion: Alone or in combination administration of BA and As induced oxidative stress in Liver mitochondria and decreased insulin secretion of pancreatic Islets.

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    APA: Copy

    AHANGARPOUR, AKRAM, OROOJAN, ALI AKBAR, REZAEI, MOHSEN, KHODAYAR, MOHAMMAD JAVAD, ALBOGHOBEISH, SOHEILA, & Zeinvand, Marzieh. (2017). Effects of butyric acid and arsenic on isolated pancreatic islets and liver mitochondria of male mouse. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, 10(1), 44-53. SID. https://sid.ir/paper/324829/en

    Vancouver: Copy

    AHANGARPOUR AKRAM, OROOJAN ALI AKBAR, REZAEI MOHSEN, KHODAYAR MOHAMMAD JAVAD, ALBOGHOBEISH SOHEILA, Zeinvand Marzieh. Effects of butyric acid and arsenic on isolated pancreatic islets and liver mitochondria of male mouse. GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH[Internet]. 2017;10(1):44-53. Available from: https://sid.ir/paper/324829/en

    IEEE: Copy

    AKRAM AHANGARPOUR, ALI AKBAR OROOJAN, MOHSEN REZAEI, MOHAMMAD JAVAD KHODAYAR, SOHEILA ALBOGHOBEISH, and Marzieh Zeinvand, “Effects of butyric acid and arsenic on isolated pancreatic islets and liver mitochondria of male mouse,” GASTROENTEROLOGY AND HEPATOLOGY FROM BED TO BENCH, vol. 10, no. 1, pp. 44–53, 2017, [Online]. Available: https://sid.ir/paper/324829/en

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